Histona_deacetilasa_4 Knowpia

Histona deacetilasa 4
	; Estructura tridimensional de la proteína HDAC4.
Estructuras disponibles
PDB	Buscar ortólogos: PDBe, RCSB
Identificadores
Símbolos	HDAC4 (HGNC: 14063) HA6116, HD4, HDAC-A, HDACA, KIAA0288
Identificadores; externos	OMIM: 605314 ; EBI: HDAC4; GeneCards: Gen HDAC4; UniProt: HDAC4;
Locus	Cr. 2 q37.3
	Referencias: AmiGO / QuickGO
Ortólogos
Humano	Ratón
9759
P56524	n/a
NP_006028	n/a
	v; t; e;
	[editar datos en Wikidata]

La histona deacetilasa 4 (HDAC4) es una enzima codificada en humanos por el gen hdac4.^[1]^[2]

Función

Las histonas juegan un papel crucial en la regulación de la transcripción, en la progresión del ciclo celular y en procesos de desarrollo. La acetilación/desacetilación de histonas altera la estructura del cromosoma, variando así la accesibilidad de los factores de transcripción al ADN. La HDAC4 pertenece a la clase II dentro de la familia de histona deacetilasas. Esta proteína no se une directamente al ADN, sino que ejerce su actividad a través de los factores de transcripción MEF2C y MEF2D. Además, parece interaccionar en un complejo multiproteico con RbAp48 y con HDAC3.^[3] HDAC4 también es necesaria en el proceso de diferenciación miofibroblástica inducida por TGF beta 1.^[4]

Importancia clínica

Diversos estudios han demostrado que HDAC4 regula el desarrollo de hueso y músculo. Investigadores de la Universidad de Harvard también han concluido que está implicada en el mantenimiento de una visión sana: reduce los niveles de proteína que inducen la muerte de los bastones fotorreceptores y de las células bipolares en la retina de ratones.^[5]^[6]

Interacciones

La histona deacetilasa 4 ha demostrado ser capaz de interaccionar con:

Véase también

Histona deacetilasa

Referencias

↑ ^a ^b Grozinger, C M; Hassig C A, Schreiber S L (Apr. de 1999). «Three proteins define a class of human histone deacetylases related to yeast Hda1p». Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 96 (9): 4868-73. ISSN 0027-8424. PMID 10220385.
↑ Fischle W, Emiliani S, Hendzel MJ, Nagase T, Nomura N, Voelter W, Verdin E (abril de 1999). «A new family of human histone deacetylases related to Saccharomyces cerevisiae HDA1p». J. Biol. Chem. 274 (17): 11713-20. PMID 10206986.
↑ «Entrez Gene: HDAC4 histone deacetylase 4».
↑ Glenisson W, Castronovo V, Waltregny D. «Histone deacetylase 4 is required for TGFbeta1-induced myofibroblastic differentiation.». Biochim Biophys Acta. 2007 Oct;1773(10):1572-82. Epub 2007 Jun 12. PMID 17610967.
↑ Protein for Sight, Scientific American, 300, 3 (March 2009), p. 23
↑ Chen B, Cepko CL (enero de 2009). «HDAC4 regulates neuronal survival in normal and diseased retinas». Science 323 (5911): 256-9. PMID 19131628. doi:10.1126/science.1166226.
↑ Wang, A H; Bertos N R, Vezmar M, Pelletier N, Crosato M, Heng H H, Th'ng J, Han J, Yang X J (Nov. de 1999). «HDAC4, a human histone deacetylase related to yeast HDA1, is a transcriptional corepressor». Mol. Cell. Biol. (UNITED STATES) 19 (11): 7816-27. ISSN 0270-7306. PMID 10523670.
↑ Wang, A H; Yang X J (Sep. de 2001). «Histone deacetylase 4 possesses intrinsic nuclear import and export signals». Mol. Cell. Biol. (United States) 21 (17): 5992-6005. ISSN 0270-7306. PMID 11486037.
↑ Chauchereau, Anne; Mathieu Marion, de Saintignon Julie, Ferreira Roger, Pritchard Linda L, Mishal Zohair, Dejean Anne, Harel-Bellan Annick (Nov. de 2004). «HDAC4 mediates transcriptional repression by the acute promyelocytic leukaemia-associated protein PLZF». Oncogene (England) 23 (54): 8777-84. ISSN 0950-9232. PMID 15467736. doi:10.1038/sj.onc.1208128.
↑ ^a ^b Lemercier, Claudie; Brocard Marie-Paule, Puvion-Dutilleul Francine, Kao Hung-Ying, Albagli Olivier, Khochbin Saadi (Jun. de 2002). «Class II histone deacetylases are directly recruited by BCL6 transcriptional repressor». J. Biol. Chem. (United States) 277 (24): 22045-52. ISSN 0021-9258. PMID 11929873. doi:10.1074/jbc.M201736200.
↑ Zhang, Chun Li; McKinsey Timothy A, Olson Eric N (Oct. de 2002). «Association of class II histone deacetylases with heterochromatin protein 1: potential role for histone methylation in control of muscle differentiation». Mol. Cell. Biol. (United States) 22 (20): 7302-12. ISSN 0270-7306. PMID 12242305.
↑ ^a ^b Zhou, X; Richon V M, Wang A H, Yang X J, Rifkind R A, Marks P A (Dec. de 2000). «Histone deacetylase 4 associates with extracellular signal-regulated kinases 1 and 2, and its cellular localization is regulated by oncogenic Ras». Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 97 (26): 14329-33. ISSN 0027-8424. PMID 11114188. doi:10.1073/pnas.250494697.
↑ Franco, Peter J; Li Guangjin, Wei Li-Na (Aug. de 2003). «Interaction of nuclear receptor zinc finger DNA binding domains with histone deacetylase». Mol. Cell. Endocrinol. (Ireland) 206 (1-2): 1-12. ISSN 0303-7207. PMID 12943985.
↑ Franco, P J; Farooqui M, Seto E, Wei L N (Aug. de 2001). «The orphan nuclear receptor TR2 interacts directly with both class I and class II histone deacetylases». Mol. Endocrinol. (United States) 15 (8): 1318-28. ISSN 0888-8809. PMID 11463856.
↑ Miska, E A; Karlsson C, Langley E, Nielsen S J, Pines J, Kouzarides T (Sep. de 1999). «HDAC4 deacetylase associates with and represses the MEF2 transcription factor». EMBO J. (ENGLAND) 18 (18): 5099-107. ISSN 0261-4189. PMID 10487761. doi:10.1093/emboj/18.18.5099.
↑ Lemercier, C; Verdel A, Galloo B, Curtet S, Brocard M P, Khochbin S (mayo. de 2000). «mHDA1/HDAC5 histone deacetylase interacts with and represses MEF2A transcriptional activity». J. Biol. Chem. (UNITED STATES) 275 (20): 15594-9. ISSN 0021-9258. PMID 10748098. doi:10.1074/jbc.M908437199.
↑ ^a ^b ^c Fischle, Wolfgang; Dequiedt Franck, Hendzel Michael J, Guenther Matthew G, Lazar Mitchell A, Voelter Wolfgang, Verdin Eric (Jan. de 2002). «Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT/N-CoR». Mol. Cell (United States) 9 (1): 45-57. ISSN 1097-2765. PMID 11804585.
↑ ^a ^b Huang, E Y; Zhang J, Miska E A, Guenther M G, Kouzarides T, Lazar M A (Jan. de 2000). «Nuclear receptor corepressors partner with class II histone deacetylases in a Sin3-independent repression pathway». Genes Dev. (UNITED STATES) 14 (1): 45-54. ISSN 0890-9369. PMID 10640275.
↑ ^a ^b ^c Grozinger, C M; Schreiber S L (Jul. de 2000). «Regulation of histone deacetylase 4 and 5 and transcriptional activity by 14-3-3-dependent cellular localization». Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 97 (14): 7835-40. ISSN 0027-8424. PMID 10869435. doi:10.1073/pnas.140199597.
↑ Fischle, W; Dequiedt F, Fillion M, Hendzel M J, Voelter W, Verdin E (Sep. de 2001). «Human HDAC7 histone deacetylase activity is associated with HDAC3 in vivo». J. Biol. Chem. (United States) 276 (38): 35826-35. ISSN 0021-9258. PMID 11466315. doi:10.1074/jbc.M104935200.
↑ Watamoto, Kouichi; Towatari Masayuki, Ozawa Yukiyasu, Miyata Yasuhiko, Okamoto Mitsunori, Abe Akihiro, Naoe Tomoki, Saito Hidehiko (Dec. de 2003). «Altered interaction of HDAC5 with GATA-1 during MEL cell differentiation». Oncogene (England) 22 (57): 9176-84. ISSN 0950-9232. PMID 14668799. doi:10.1038/sj.onc.1206902.
↑ Miska, E A; Langley E; Wolf D; Karlsson C; Pines J; Kouzarides T (Aug. de 2001). «Differential localization of HDAC4 orchestrates muscle differentiation». Nucleic Acids Res. (England) 29 (16): 3439-47. PMID 11504882.

Enlaces externos

MeSH: HDAC4+protein,+human (en inglés)

Datos: Q21173206

[pmid10220385-1] Grozinger, C M; Hassig C A, Schreiber S L (Apr. de 1999). «Three proteins define a class of human histone deacetylases related to yeast Hda1p». Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 96 (9): 4868-73. ISSN 0027-8424. PMID 10220385.

[pmid10206986-2] Fischle W, Emiliani S, Hendzel MJ, Nagase T, Nomura N, Voelter W, Verdin E (abril de 1999). «A new family of human histone deacetylases related to Saccharomyces cerevisiae HDA1p». J. Biol. Chem. 274 (17): 11713-20. PMID 10206986.

[entrez-3] «Entrez Gene: HDAC4 histone deacetylase 4».

[4] Glenisson W, Castronovo V, Waltregny D. «Histone deacetylase 4 is required for TGFbeta1-induced myofibroblastic differentiation.». Biochim Biophys Acta. 2007 Oct;1773(10):1572-82. Epub 2007 Jun 12. PMID 17610967.

[5] Protein for Sight, Scientific American, 300, 3 (March 2009), p. 23

[pmid19131628-6] Chen B, Cepko CL (enero de 2009). «HDAC4 regulates neuronal survival in normal and diseased retinas». Science 323 (5911): 256-9. PMID 19131628. doi:10.1126/science.1166226.

[pmid10523670-7] Wang, A H; Bertos N R, Vezmar M, Pelletier N, Crosato M, Heng H H, Th'ng J, Han J, Yang X J (Nov. de 1999). «HDAC4, a human histone deacetylase related to yeast HDA1, is a transcriptional corepressor». Mol. Cell. Biol. (UNITED STATES) 19 (11): 7816-27. ISSN 0270-7306. PMID 10523670.

[pmid11486037-8] Wang, A H; Yang X J (Sep. de 2001). «Histone deacetylase 4 possesses intrinsic nuclear import and export signals». Mol. Cell. Biol. (United States) 21 (17): 5992-6005. ISSN 0270-7306. PMID 11486037.

[pmid15467736-9] Chauchereau, Anne; Mathieu Marion, de Saintignon Julie, Ferreira Roger, Pritchard Linda L, Mishal Zohair, Dejean Anne, Harel-Bellan Annick (Nov. de 2004). «HDAC4 mediates transcriptional repression by the acute promyelocytic leukaemia-associated protein PLZF». Oncogene (England) 23 (54): 8777-84. ISSN 0950-9232. PMID 15467736. doi:10.1038/sj.onc.1208128.

[pmid11929873-10] Lemercier, Claudie; Brocard Marie-Paule, Puvion-Dutilleul Francine, Kao Hung-Ying, Albagli Olivier, Khochbin Saadi (Jun. de 2002). «Class II histone deacetylases are directly recruited by BCL6 transcriptional repressor». J. Biol. Chem. (United States) 277 (24): 22045-52. ISSN 0021-9258. PMID 11929873. doi:10.1074/jbc.M201736200.

[pmid12242305-11] Zhang, Chun Li; McKinsey Timothy A, Olson Eric N (Oct. de 2002). «Association of class II histone deacetylases with heterochromatin protein 1: potential role for histone methylation in control of muscle differentiation». Mol. Cell. Biol. (United States) 22 (20): 7302-12. ISSN 0270-7306. PMID 12242305.

[pmid11114188-12] Zhou, X; Richon V M, Wang A H, Yang X J, Rifkind R A, Marks P A (Dec. de 2000). «Histone deacetylase 4 associates with extracellular signal-regulated kinases 1 and 2, and its cellular localization is regulated by oncogenic Ras». Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 97 (26): 14329-33. ISSN 0027-8424. PMID 11114188. doi:10.1073/pnas.250494697.

[pmid12943985-13] Franco, Peter J; Li Guangjin, Wei Li-Na (Aug. de 2003). «Interaction of nuclear receptor zinc finger DNA binding domains with histone deacetylase». Mol. Cell. Endocrinol. (Ireland) 206 (1-2): 1-12. ISSN 0303-7207. PMID 12943985.

[pmid11463856-14] Franco, P J; Farooqui M, Seto E, Wei L N (Aug. de 2001). «The orphan nuclear receptor TR2 interacts directly with both class I and class II histone deacetylases». Mol. Endocrinol. (United States) 15 (8): 1318-28. ISSN 0888-8809. PMID 11463856.

[pmid10487761-15] Miska, E A; Karlsson C, Langley E, Nielsen S J, Pines J, Kouzarides T (Sep. de 1999). «HDAC4 deacetylase associates with and represses the MEF2 transcription factor». EMBO J. (ENGLAND) 18 (18): 5099-107. ISSN 0261-4189. PMID 10487761. doi:10.1093/emboj/18.18.5099.

[pmid10748098-16] Lemercier, C; Verdel A, Galloo B, Curtet S, Brocard M P, Khochbin S (mayo. de 2000). «mHDA1/HDAC5 histone deacetylase interacts with and represses MEF2A transcriptional activity». J. Biol. Chem. (UNITED STATES) 275 (20): 15594-9. ISSN 0021-9258. PMID 10748098. doi:10.1074/jbc.M908437199.

[pmid11804585-17] Fischle, Wolfgang; Dequiedt Franck, Hendzel Michael J, Guenther Matthew G, Lazar Mitchell A, Voelter Wolfgang, Verdin Eric (Jan. de 2002). «Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT/N-CoR». Mol. Cell (United States) 9 (1): 45-57. ISSN 1097-2765. PMID 11804585.

[pmid10640275-18] Huang, E Y; Zhang J, Miska E A, Guenther M G, Kouzarides T, Lazar M A (Jan. de 2000). «Nuclear receptor corepressors partner with class II histone deacetylases in a Sin3-independent repression pathway». Genes Dev. (UNITED STATES) 14 (1): 45-54. ISSN 0890-9369. PMID 10640275.

[pmid10869435-19] Grozinger, C M; Schreiber S L (Jul. de 2000). «Regulation of histone deacetylase 4 and 5 and transcriptional activity by 14-3-3-dependent cellular localization». Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 97 (14): 7835-40. ISSN 0027-8424. PMID 10869435. doi:10.1073/pnas.140199597.

[pmid11466315-20] Fischle, W; Dequiedt F, Fillion M, Hendzel M J, Voelter W, Verdin E (Sep. de 2001). «Human HDAC7 histone deacetylase activity is associated with HDAC3 in vivo». J. Biol. Chem. (United States) 276 (38): 35826-35. ISSN 0021-9258. PMID 11466315. doi:10.1074/jbc.M104935200.

[pmid14668799-21] Watamoto, Kouichi; Towatari Masayuki, Ozawa Yukiyasu, Miyata Yasuhiko, Okamoto Mitsunori, Abe Akihiro, Naoe Tomoki, Saito Hidehiko (Dec. de 2003). «Altered interaction of HDAC5 with GATA-1 during MEL cell differentiation». Oncogene (England) 22 (57): 9176-84. ISSN 0950-9232. PMID 14668799. doi:10.1038/sj.onc.1206902.

[pmid11504882-22] Miska, E A; Langley E; Wolf D; Karlsson C; Pines J; Kouzarides T (Aug. de 2001). «Differential localization of HDAC4 orchestrates muscle differentiation». Nucleic Acids Res. (England) 29 (16): 3439-47. PMID 11504882.

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