RRAS Knowpia

Related RAS viral (r-ras) oncogene homolog
	; Estructura tridimensional de la proteína RRAS.
Estructuras disponibles
PDB	Buscar ortólogos: PDBe, RCSB Lista de códigos PDB 2fn4
Identificadores
Símbolo	RRAS (HGNC: 10447)
Identificadores; externos	OMIM: 165090 ; EBI: RRAS; GeneCards: Gen RRAS; UniProt: RRAS;
Locus	Cr. 19 q13.33
	Referencias: AmiGO / QuickGO
Ortólogos
Humano	Ratón
6237
P10301	n/a
NP_006261	n/a
	v; t; e;
	[editar datos en Wikidata]

La proteína R-Ras asociada a Ras (RRAS) es una proteína codificada en humanos por el gen RRAS.^[1]^[2]

Interacciones

La proteína RRAS ha demostrado ser capaz de interaccionar con:

RASSF5^[3]
NCK1^[4]
Bcl-2^[5]
ARAF^[6]^[7]
RALGDS^[8]

Referencias

↑ Lowe DG, Capon DJ, Delwart E, Sakaguchi AY, Naylor SL, Goeddel DV (Feb de 1987). «Structure of the human and murine R-ras genes, novel genes closely related to ras proto-oncogenes». Cell 48 (1): 137-46. PMID 3098437.
↑ «Entrez Gene: RRAS related RAS viral (r-ras) oncogene homolog».
↑ Ortiz-Vega, Sara; Khokhlatchev Andrei, Nedwidek Maria, Zhang Xian-feng, Dammann Reinhard, Pfeifer Gerd P, Avruch Joseph (Feb. de 2002). «The putative tumor suppressor RASSF1A homodimerizes and heterodimerizes with the Ras-GTP binding protein Nore1». Oncogene (England) 21 (9): 1381-90. ISSN 0950-9232. PMID 11857081. doi:10.1038/sj.onc.1205192.
↑ Wang, B; Zou J X, Ek-Rylander B, Ruoslahti E (Feb. de 2000). «R-Ras contains a proline-rich site that binds to SH3 domains and is required for integrin activation by R-Ras». J. Biol. Chem. (UNITED STATES) 275 (7): 5222-7. ISSN 0021-9258. PMID 10671570.
↑ Fernandez-Sarabia, M J; Bischoff J R (Nov. de 1993). «Bcl-2 associates with the ras-related protein R-ras p23». Nature (ENGLAND) 366 (6452): 274-5. ISSN 0028-0836. PMID 8232588. doi:10.1038/366274a0.
↑ Yuryev, Anton; Wennogle Lawrence P (Feb. de 2003). «Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid analysis». Genomics (United States) 81 (2): 112-25. ISSN 0888-7543. PMID 12620389.
↑ Yuryev, A; Ono M, Goff S A, Macaluso F, Wennogle L P (Jul. de 2000). «Isoform-specific localization of A-RAF in mitochondria». Mol. Cell. Biol. (UNITED STATES) 20 (13): 4870-8. ISSN 0270-7306. PMID 10848612.
↑ Spaargaren, M; Bischoff J R (Dec. de 1994). «Identification of the guanine nucleotide dissociation stimulator for Ral as a putative effector molecule of R-ras, H-ras, K-ras, and Rap». Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 91 (26): 12609-13. ISSN 0027-8424. PMID 7809086.

Datos: Q18031323

[pmid3098437-1] Lowe DG, Capon DJ, Delwart E, Sakaguchi AY, Naylor SL, Goeddel DV (Feb de 1987). «Structure of the human and murine R-ras genes, novel genes closely related to ras proto-oncogenes». Cell 48 (1): 137-46. PMID 3098437.

[entrez-2] «Entrez Gene: RRAS related RAS viral (r-ras) oncogene homolog».

[pmid11857081-3] Ortiz-Vega, Sara; Khokhlatchev Andrei, Nedwidek Maria, Zhang Xian-feng, Dammann Reinhard, Pfeifer Gerd P, Avruch Joseph (Feb. de 2002). «The putative tumor suppressor RASSF1A homodimerizes and heterodimerizes with the Ras-GTP binding protein Nore1». Oncogene (England) 21 (9): 1381-90. ISSN 0950-9232. PMID 11857081. doi:10.1038/sj.onc.1205192.

[pmid10671570-4] Wang, B; Zou J X, Ek-Rylander B, Ruoslahti E (Feb. de 2000). «R-Ras contains a proline-rich site that binds to SH3 domains and is required for integrin activation by R-Ras». J. Biol. Chem. (UNITED STATES) 275 (7): 5222-7. ISSN 0021-9258. PMID 10671570.

[pmid8232588-5] Fernandez-Sarabia, M J; Bischoff J R (Nov. de 1993). «Bcl-2 associates with the ras-related protein R-ras p23». Nature (ENGLAND) 366 (6452): 274-5. ISSN 0028-0836. PMID 8232588. doi:10.1038/366274a0.

[pmid12620389-6] Yuryev, Anton; Wennogle Lawrence P (Feb. de 2003). «Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid analysis». Genomics (United States) 81 (2): 112-25. ISSN 0888-7543. PMID 12620389.

[pmid10848612-7] Yuryev, A; Ono M, Goff S A, Macaluso F, Wennogle L P (Jul. de 2000). «Isoform-specific localization of A-RAF in mitochondria». Mol. Cell. Biol. (UNITED STATES) 20 (13): 4870-8. ISSN 0270-7306. PMID 10848612.

[pmid7809086-8] Spaargaren, M; Bischoff J R (Dec. de 1994). «Identification of the guanine nucleotide dissociation stimulator for Ral as a putative effector molecule of R-ras, H-ras, K-ras, and Rap». Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 91 (26): 12609-13. ISSN 0027-8424. PMID 7809086.

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Summary

Interacciones

Referencias