RALGDS Knowpia

RALGDS
Estructuras disponibles
PDB	Buscar ortólogos:
Identificadores
Identificadores; externos	EBI: RALGDS; UniProt: RALGDS;
	Referencias: AmiGO / QuickGO
Q9ZWS9	n/a
	v; t; e;
	[editar datos en Wikidata]

Estimulador de disociación de nucleótidos de guanina ral (RALGDS) es una proteína que en los humanos está codificado por el gen RALGDS.^[1]^[2]

Interacciones

RALGDS ha sido mostrado para interaccionar con:

Arrestin beta 1,^[3]
Arrestin beta 2,^[3]
HRAS,^[1]^[4]^[5]^[6]^[7]^[8]^[9]^[10]
KRAS,^[4]^[6]
MRAS,^[11]^[12]
RAP1A,^[5]^[13]
RAP2A,^[13]
RAPGEF2,^[4] y
RRAS.^[4]

Referencias

↑ ^a ^b «Activated Ras interacts with the Ral guanine nucleotide dissociation stimulator». Proc Natl Acad Sci U S A 91 (23): 11089-93. December 1994. PMC 45172. PMID 7972015. doi:10.1073/pnas.91.23.11089.
↑ «Entrez Gene: RALGDS ral guanine nucleotide dissociation stimulator».
↑ ^a ^b Bhattacharya M, Anborgh PH, Babwah AV, Dale LB, Dobransky T, Benovic JL, Feldman RD, Verdi JM, Rylett RJ, Ferguson SS (August 2002). «Beta-arrestins regulate a Ral-GDS Ral effector pathway that mediates cytoskeletal reorganization». Nat. Cell Biol. 4 (8): 547-55. PMID 12105416.
↑ ^a ^b ^c ^d Spaargaren M, Bischoff JR (Diciembre de 1994). «Identification of the guanine nucleotide dissociation stimulator for Ral as a putative effector molecule of R-ras, H-ras, K-ras, and Rap». Proc. Natl. Acad. Sci. U.S.A. 91 (26): 12609-13. PMC 45488. PMID 7809086.
↑ ^a ^b Boettner B, Govek EE, Cross J, Van Aelst L (Agosto de 2000). «The junctional multidomain protein AF-6 is a binding partner of the Rap1A GTPase and associates with the actin cytoskeletal regulator profilin». Proc. Natl. Acad. Sci. U.S.A. 97 (16): 9064-9. PMC 16822. PMID 10922060.
↑ ^a ^b Li W, Han M, Guan KL (Abril de 2000). «The leucine-rich repeat protein SUR-8 enhances MAP kinase activation and forms a complex with Ras and Raf». Genes Dev. 14 (8): 895-900. PMC 316541. PMID 10783161.
↑ Mitin NY, Ramocki MB, Zullo AJ, Der CJ, Konieczny SF, Taparowsky EJ (Mayo de 2004). «Identification and characterization of rain, a novel Ras-interacting protein with a unique subcellular localization». J. Biol. Chem. 279 (21): 22353-61. PMID 15031288.
↑ Miller MJ, Prigent S, Kupperman E, Rioux L, Park SH, Feramisco JR, White MA, Rutkowski JL, Meinkoth JL (Febrero de 1997). «RalGDS functions in Ras- and cAMP-mediated growth stimulation». J. Biol. Chem. 272 (9): 5600-5. PMID 9038168.
↑ Rodriguez-Viciana P, Warne PH, Khwaja A, Marte BM, Pappin D, Das P, Waterfield MD, Ridley A, Downward J (Mayo de 1997). «Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras». Cell 89 (3): 457-67. PMID 9150145.
↑ Stang S, Bottorff D, Stone JC (Junio de 1997). «Interaction of activated Ras with Raf-1 alone may be sufficient for transformation of rat2 cells». Mol. Cell. Biol. 17 (6): 3047-55. PMC 232157. PMID 9154803.
↑ Kimmelman A, Tolkacheva T, Lorenzi MV, Osada M, Chan AM (Noviembre de 1997). «Identification and characterization of R-ras3: a novel member of the RAS gene family with a non-ubiquitous pattern of tissue distribution». Oncogene 15 (22): 2675-85. PMID 9400994.
↑ Ehrhardt GR, Leslie KB, Lee F, Wieler JS, Schrader JW (Octubre de 1999). «M-Ras, a widely expressed 29-kD homologue of p21 Ras: expression of a constitutively active mutant results in factor-independent growth of an interleukin-3-dependent cell line». Blood 94 (7): 2433-44. PMID 10498616.
↑ ^a ^b Nancy V, Wolthuis RM, de Tand MF, Janoueix-Lerosey I, Bos JL, de Gunzburg J (Marzo de 1999). «Identification and characterization of potential effector molecules of the Ras-related GTPase Rap2». J. Biol. Chem. 274 (13): 8737-45. PMID 10085114.

Enlaces externos

Esta obra contiene una traducción derivada de «RALGDS» de Wikipedia en inglés, publicada por sus editores bajo la Licencia de documentación libre de GNU y la Licencia Creative Commons Atribución-CompartirIgual 4.0 Internacional.

Datos: Q18031027

[pmid7972015-1] «Activated Ras interacts with the Ral guanine nucleotide dissociation stimulator». Proc Natl Acad Sci U S A 91 (23): 11089-93. December 1994. PMC 45172. PMID 7972015. doi:10.1073/pnas.91.23.11089.

[entrez-2] «Entrez Gene: RALGDS ral guanine nucleotide dissociation stimulator».

[pmid12105416-3] Bhattacharya M, Anborgh PH, Babwah AV, Dale LB, Dobransky T, Benovic JL, Feldman RD, Verdi JM, Rylett RJ, Ferguson SS (August 2002). «Beta-arrestins regulate a Ral-GDS Ral effector pathway that mediates cytoskeletal reorganization». Nat. Cell Biol. 4 (8): 547-55. PMID 12105416.

[pmid7809086-4] Spaargaren M, Bischoff JR (Diciembre de 1994). «Identification of the guanine nucleotide dissociation stimulator for Ral as a putative effector molecule of R-ras, H-ras, K-ras, and Rap». Proc. Natl. Acad. Sci. U.S.A. 91 (26): 12609-13. PMC 45488. PMID 7809086.

[pmid10922060-5] Boettner B, Govek EE, Cross J, Van Aelst L (Agosto de 2000). «The junctional multidomain protein AF-6 is a binding partner of the Rap1A GTPase and associates with the actin cytoskeletal regulator profilin». Proc. Natl. Acad. Sci. U.S.A. 97 (16): 9064-9. PMC 16822. PMID 10922060.

[pmid10783161-6] Li W, Han M, Guan KL (Abril de 2000). «The leucine-rich repeat protein SUR-8 enhances MAP kinase activation and forms a complex with Ras and Raf». Genes Dev. 14 (8): 895-900. PMC 316541. PMID 10783161.

[pmid15031288-7] Mitin NY, Ramocki MB, Zullo AJ, Der CJ, Konieczny SF, Taparowsky EJ (Mayo de 2004). «Identification and characterization of rain, a novel Ras-interacting protein with a unique subcellular localization». J. Biol. Chem. 279 (21): 22353-61. PMID 15031288.

[pmid9038168-8] Miller MJ, Prigent S, Kupperman E, Rioux L, Park SH, Feramisco JR, White MA, Rutkowski JL, Meinkoth JL (Febrero de 1997). «RalGDS functions in Ras- and cAMP-mediated growth stimulation». J. Biol. Chem. 272 (9): 5600-5. PMID 9038168.

[pmid9150145-9] Rodriguez-Viciana P, Warne PH, Khwaja A, Marte BM, Pappin D, Das P, Waterfield MD, Ridley A, Downward J (Mayo de 1997). «Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras». Cell 89 (3): 457-67. PMID 9150145.

[pmid9154803-10] Stang S, Bottorff D, Stone JC (Junio de 1997). «Interaction of activated Ras with Raf-1 alone may be sufficient for transformation of rat2 cells». Mol. Cell. Biol. 17 (6): 3047-55. PMC 232157. PMID 9154803.

[pmid9400994-11] Kimmelman A, Tolkacheva T, Lorenzi MV, Osada M, Chan AM (Noviembre de 1997). «Identification and characterization of R-ras3: a novel member of the RAS gene family with a non-ubiquitous pattern of tissue distribution». Oncogene 15 (22): 2675-85. PMID 9400994.

[pmid10498616-12] Ehrhardt GR, Leslie KB, Lee F, Wieler JS, Schrader JW (Octubre de 1999). «M-Ras, a widely expressed 29-kD homologue of p21 Ras: expression of a constitutively active mutant results in factor-independent growth of an interleukin-3-dependent cell line». Blood 94 (7): 2433-44. PMID 10498616.

[pmid10085114-13] Nancy V, Wolthuis RM, de Tand MF, Janoueix-Lerosey I, Bos JL, de Gunzburg J (Marzo de 1999). «Identification and characterization of potential effector molecules of the Ras-related GTPase Rap2». J. Biol. Chem. 274 (13): 8737-45. PMID 10085114.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

[12]

[13]

Summary

Interacciones

Referencias

Enlaces externos