RANBP9 Knowpia

Proteína de unión a RAN 9
Estructuras disponibles
PDB	Buscar ortólogos: PDBe, RCSB
Identificadores
Símbolos	RANBP9 (HGNC: 13727) RANBPM
Identificadores; externos	OMIM: 603854 ; EBI: RANBP9; GeneCards: Gen RANBP9; UniProt: RANBP9;
Locus	Cr. 6 p23
	Referencias: AmiGO / QuickGO
Ortólogos
Humano	Ratón
10048
Q96S59	n/a
NP_005484	n/a
	v; t; e;
	[editar datos en Wikidata]

La proteína de unión a RAN 9 (RANBP9) es una proteína codificada en humanos por el gen ranbp9.^[1]^[2]^[3]

Este gen codifica una proteína que se une a RAN, una proteína que une GTP perteneciente a la superfamilia Ras esencial en la translocación de ARN y ciertas proteínas a través del poro nuclear hacia el núcleo celular. RANBP9 también ha demostrado interaccionar con otras proteínas como los proto-oncogenes c-Met, HIPK2, el receptor androgénico y Cdk11.^[3]

Interacciones

La proteína RANBP9 ha demostrado ser capaz de interaccionar con:

c-Met^[4]
DYRK1B^[5]
USP11^[6]
DISC1^[7]
Receptor androgénico^[8]
Receptor de glucocorticoides^[8]
S100A7^[9]
HIPK2^[10]
MKLN1^[11]

Referencias

↑ Nakamura M, Masuda H, Horii J, Kuma K, Yokoyama N, Ohba T, Nishitani H, Miyata T, Tanaka M, Nishimoto T (Dec de 1998). «When overexpressed, a novel centrosomal protein, RanBPM, causes ectopic microtubule nucleation similar to gamma-tubulin». J Cell Biol 143 (4): 1041-52. PMC 2132962. PMID 9817760.
↑ Murrin LC, Talbot JN (Sep de 2007). «RanBPM, a scaffolding protein in the immune and nervous systems». J Neuroimmune Pharmacol 2 (3): 290-295. PMID 18040864.
↑ ^a ^b «Entrez Gene: RANBP9 RAN binding protein 9».
↑ Wang, Dakun; Li Zaibo, Messing Edward M, Wu Guan (Sep. de 2002). «Activation of Ras/Erk pathway by a novel MET-interacting protein RanBPM». J. Biol. Chem. (United States) 277 (39): 36216-22. ISSN 0021-9258. PMID 12147692. doi:10.1074/jbc.M205111200.
↑ Zou, Yonglong; Lim Seunghwan, Lee Kangmoon, Deng Xiaobing, Friedman Eileen (Dec. de 2003). «Serine/threonine kinase Mirk/Dyrk1B is an inhibitor of epithelial cell migration and is negatively regulated by the Met adaptor Ran-binding protein M». J. Biol. Chem. (United States) 278 (49): 49573-81. ISSN 0021-9258. PMID 14500717. doi:10.1074/jbc.M307556200.
↑ Ideguchi, Haruko; Ueda Atsuhisa, Tanaka Masatsugu, Yang Jun, Tsuji Takashi, Ohno Shigeru, Hagiwara Eri, Aoki Akiko, Ishigatsubo Yoshiaki (Oct. de 2002). «Structural and functional characterization of the USP11 deubiquitinating enzyme, which interacts with the RanGTP-associated protein RanBPM». Biochem. J. (England) 367 (Pt 1): 87-95. ISSN 0264-6021. PMID 12084015. doi:10.1042/BJ20011851.
↑ Morris, Jill A; Kandpal Geeta, Ma Lei, Austin Christopher P (Jul. de 2003). «DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation». Hum. Mol. Genet. (England) 12 (13): 1591-608. ISSN 0964-6906. PMID 12812986.
↑ ^a ^b Rao, Mira A; Cheng Helen, Quayle Alandra N, Nishitani Hideo, Nelson Colleen C, Rennie Paul S (Dec. de 2002). «RanBPM, a nuclear protein that interacts with and regulates transcriptional activity of androgen receptor and glucocorticoid receptor». J. Biol. Chem. (United States) 277 (50): 48020-7. ISSN 0021-9258. PMID 12361945. doi:10.1074/jbc.M209741200.
↑ Emberley, Ethan D; Gietz R Daniel, Campbell J Darren, HayGlass Kent T, Murphy Leigh C, Watson Peter H (Nov. de 2002). «RanBPM interacts with psoriasin in vitro and their expression correlates with specific clinical features in vivo in breast cancer». BMC Cancer (England) 2: 28. PMID 12421467.
↑ Wang, Ying; Marion Schneider E, Li Xin, Duttenhöfer Irina, Debatin Klaus, Hug Hubert (Sep. de 2002). «HIPK2 associates with RanBPM». Biochem. Biophys. Res. Commun. (United States) 297 (1): 148-53. ISSN 0006-291X. PMID 12220523.
↑ Umeda, M; Nishitani H; Nishimoto T (Jan. de 2003). «A novel nuclear protein, Twa1, and Muskelin comprise a complex with RanBPM». Gene (Netherlands) 303: 47-54. ISSN 0378-1119. PMID 12559565.

Enlaces externos

MeSH: RANBP9+protein,+human (en inglés)

Datos: Q18258603

[pmid9817760-1] Nakamura M, Masuda H, Horii J, Kuma K, Yokoyama N, Ohba T, Nishitani H, Miyata T, Tanaka M, Nishimoto T (Dec de 1998). «When overexpressed, a novel centrosomal protein, RanBPM, causes ectopic microtubule nucleation similar to gamma-tubulin». J Cell Biol 143 (4): 1041-52. PMC 2132962. PMID 9817760.

[pmid18040864-2] Murrin LC, Talbot JN (Sep de 2007). «RanBPM, a scaffolding protein in the immune and nervous systems». J Neuroimmune Pharmacol 2 (3): 290-295. PMID 18040864.

[entrez-3] «Entrez Gene: RANBP9 RAN binding protein 9».

[pmid12147692-4] Wang, Dakun; Li Zaibo, Messing Edward M, Wu Guan (Sep. de 2002). «Activation of Ras/Erk pathway by a novel MET-interacting protein RanBPM». J. Biol. Chem. (United States) 277 (39): 36216-22. ISSN 0021-9258. PMID 12147692. doi:10.1074/jbc.M205111200.

[pmid14500717-5] Zou, Yonglong; Lim Seunghwan, Lee Kangmoon, Deng Xiaobing, Friedman Eileen (Dec. de 2003). «Serine/threonine kinase Mirk/Dyrk1B is an inhibitor of epithelial cell migration and is negatively regulated by the Met adaptor Ran-binding protein M». J. Biol. Chem. (United States) 278 (49): 49573-81. ISSN 0021-9258. PMID 14500717. doi:10.1074/jbc.M307556200.

[pmid12084015-6] Ideguchi, Haruko; Ueda Atsuhisa, Tanaka Masatsugu, Yang Jun, Tsuji Takashi, Ohno Shigeru, Hagiwara Eri, Aoki Akiko, Ishigatsubo Yoshiaki (Oct. de 2002). «Structural and functional characterization of the USP11 deubiquitinating enzyme, which interacts with the RanGTP-associated protein RanBPM». Biochem. J. (England) 367 (Pt 1): 87-95. ISSN 0264-6021. PMID 12084015. doi:10.1042/BJ20011851.

[pmid12812986-7] Morris, Jill A; Kandpal Geeta, Ma Lei, Austin Christopher P (Jul. de 2003). «DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation». Hum. Mol. Genet. (England) 12 (13): 1591-608. ISSN 0964-6906. PMID 12812986.

[pmid12361945-8] Rao, Mira A; Cheng Helen, Quayle Alandra N, Nishitani Hideo, Nelson Colleen C, Rennie Paul S (Dec. de 2002). «RanBPM, a nuclear protein that interacts with and regulates transcriptional activity of androgen receptor and glucocorticoid receptor». J. Biol. Chem. (United States) 277 (50): 48020-7. ISSN 0021-9258. PMID 12361945. doi:10.1074/jbc.M209741200.

[pmid12421467-9] Emberley, Ethan D; Gietz R Daniel, Campbell J Darren, HayGlass Kent T, Murphy Leigh C, Watson Peter H (Nov. de 2002). «RanBPM interacts with psoriasin in vitro and their expression correlates with specific clinical features in vivo in breast cancer». BMC Cancer (England) 2: 28. PMID 12421467.

[pmid12220523-10] Wang, Ying; Marion Schneider E, Li Xin, Duttenhöfer Irina, Debatin Klaus, Hug Hubert (Sep. de 2002). «HIPK2 associates with RanBPM». Biochem. Biophys. Res. Commun. (United States) 297 (1): 148-53. ISSN 0006-291X. PMID 12220523.

[pmid12559565-11] Umeda, M; Nishitani H; Nishimoto T (Jan. de 2003). «A novel nuclear protein, Twa1, and Muskelin comprise a complex with RanBPM». Gene (Netherlands) 303: 47-54. ISSN 0378-1119. PMID 12559565.

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Summary

Interacciones

Referencias

Enlaces externos