Nucleolina Knowpia

Nucleolina
	; Estructura tridimensional de la nucleolina.
Estructuras disponibles
PDB	Buscar ortólogos: PDBe, RCSB Lista de códigos PDB 2fc8
Identificadores
Símbolos	NCL (HGNC: 7667) C23; FLJ45706
Identificadores; externos	OMIM: 164035 ; EBI: NCL; GeneCards: Gen NCL; UniProt: NCL;
Locus	Cr. 2 q37.1
	Referencias: AmiGO / QuickGO
Ortólogos
Humano	Ratón
4691
P19338	n/a
NP_005372	n/a
	v; t; e;
	[editar datos en Wikidata]

La nucleolina (NCL) es una proteína codificada en humanos por el gen NCL.^[1]^[2]

La nucleolina, una fosfoproteína nucleolar eucariótica, está implicada en la síntesis y maduración de los ribosomas. Se localiza principalmente en regiones fibrilares densas del nucleolo. El gen de la nucleolina humana consta de 14 exones y 13 intrones, extendiéndose a lo largo de aproximadamente 11.000 pares de bases. El intrón 11 del gen NCL codifica un ARN pequeño nucleolar, denominado U20.^[3]

Interacciones

La nucleolina ha demostrado ser capaz de interaccionar con:

PPP1CB^[4]
Centaurina alfa 1^[5]
CSNK2A2^[6]
Antígeno B del síndrome de Sjogren^[7]
TOP1^[8]^[9]
p53^[10]
S100A11^[11]
NPM1^[12]
Telomerasa transcriptasa inversa^[13]

Referencias

↑ Srivastava M, McBride OW, Fleming PJ, Pollard HB, Burns AL (Oct de 1990). «Genomic organization and chromosomal localization of the human nucleolin gene». J Biol Chem 265 (25): 14922-31. PMID 2394707.
↑ Erard MS, Belenguer P, Caizergues-Ferrer M, Pantaloni A, Amalric F (Oct de 1988). «A major nucleolar protein, nucleolin, induces chromatin decondensation by binding to histone H1». Eur J Biochem 175 (3): 525-30. PMID 3409881.
↑ «Entrez Gene: NCL nucleolin».
↑ Morimoto, Hiroyuki; Okamura Hirohiko, Haneji Tatsuji (Sep. de 2002). «Interaction of protein phosphatase 1 delta with nucleolin in human osteoblastic cells». J. Histochem. Cytochem. (United States) 50 (9): 1187-93. ISSN 0022-1554. PMID 12185196.
↑ Dubois, Thierry; Zemlickova Eva, Howell Steven, Aitken Alastair (Feb. de 2003). «Centaurin-alpha 1 associates in vitro and in vivo with nucleolin». Biochem. Biophys. Res. Commun. (United States) 301 (2): 502-8. ISSN 0006-291X. PMID 12565890.
↑ Li, D; Dobrowolska G, Krebs E G (Jun. de 1996). «The physical association of casein kinase 2 with nucleolin». J. Biol. Chem. (UNITED STATES) 271 (26): 15662-8. ISSN 0021-9258. PMID 8663258.
↑ Fouraux, Michael A; Bouvet Philippe, Verkaart Sjoerd, van Venrooij Walther J, Pruijn Ger J M (Jul. de 2002). «Nucleolin associates with a subset of the human Ro ribonucleoprotein complexes». J. Mol. Biol. (England) 320 (3): 475-88. ISSN 0022-2836. PMID 12096904.
↑ Haluska, P; Saleem A, Edwards T K, Rubin E H (Apr. de 1998). «Interaction between the N-terminus of human topoisomerase I and SV40 large T antigen». Nucleic Acids Res. (ENGLAND) 26 (7): 1841-7. ISSN 0305-1048. PMID 9512561.
↑ Bharti, A K; Olson M O, Kufe D W, Rubin E H (Jan. de 1996). «Identification of a nucleolin binding site in human topoisomerase I». J. Biol. Chem. (UNITED STATES) 271 (4): 1993-7. ISSN 0021-9258. PMID 8567649.
↑ Daniely, Yaron; Dimitrova Diana D, Borowiec James A (Aug. de 2002). «Stress-dependent nucleolin mobilization mediated by p53-nucleolin complex formation». Mol. Cell. Biol. (United States) 22 (16): 6014-22. ISSN 0270-7306. PMID 12138209.
↑ Sakaguchi, Masakiyo; Miyazaki Masahiro, Takaishi Mikiro, Sakaguchi Yoshihiko, Makino Eiichi, Kataoka Noriyuki, Yamada Hidenori, Namba Masayoshi, Huh Nam-ho (Nov. de 2003). «S100C/A11 is a key mediator of Ca(2+)-induced growth inhibition of human epidermal keratinocytes». J. Cell Biol. (United States) 163 (4): 825-35. ISSN 0021-9525. PMID 14623863. doi:10.1083/jcb.200304017.
↑ Li, Y P; Busch R K, Valdez B C, Busch H (Apr. de 1996). «C23 interacts with B23, a putative nucleolar-localization-signal-binding protein». Eur. J. Biochem. (GERMANY) 237 (1): 153-8. ISSN 0014-2956. PMID 8620867.
↑ Khurts, Shilagardi; Masutomi Kenkichi, Delgermaa Luvsanjav, Arai Kuniaki, Oishi Naoki, Mizuno Hideki, Hayashi Naoyuki, Hahn William C, Murakami Seishi (Dec. de 2004). «Nucleolin interacts with telomerase». J. Biol. Chem. (United States) 279 (49): 51508-15. ISSN 0021-9258. PMID 15371412. doi:10.1074/jbc.M407643200.

Datos: Q18029887

[pmid2394707-1] Srivastava M, McBride OW, Fleming PJ, Pollard HB, Burns AL (Oct de 1990). «Genomic organization and chromosomal localization of the human nucleolin gene». J Biol Chem 265 (25): 14922-31. PMID 2394707.

[pmid3409881-2] Erard MS, Belenguer P, Caizergues-Ferrer M, Pantaloni A, Amalric F (Oct de 1988). «A major nucleolar protein, nucleolin, induces chromatin decondensation by binding to histone H1». Eur J Biochem 175 (3): 525-30. PMID 3409881.

[entrez-3] «Entrez Gene: NCL nucleolin».

[pmid12185196-4] Morimoto, Hiroyuki; Okamura Hirohiko, Haneji Tatsuji (Sep. de 2002). «Interaction of protein phosphatase 1 delta with nucleolin in human osteoblastic cells». J. Histochem. Cytochem. (United States) 50 (9): 1187-93. ISSN 0022-1554. PMID 12185196.

[pmid12565890-5] Dubois, Thierry; Zemlickova Eva, Howell Steven, Aitken Alastair (Feb. de 2003). «Centaurin-alpha 1 associates in vitro and in vivo with nucleolin». Biochem. Biophys. Res. Commun. (United States) 301 (2): 502-8. ISSN 0006-291X. PMID 12565890.

[pmid8663258-6] Li, D; Dobrowolska G, Krebs E G (Jun. de 1996). «The physical association of casein kinase 2 with nucleolin». J. Biol. Chem. (UNITED STATES) 271 (26): 15662-8. ISSN 0021-9258. PMID 8663258.

[pmid12096904-7] Fouraux, Michael A; Bouvet Philippe, Verkaart Sjoerd, van Venrooij Walther J, Pruijn Ger J M (Jul. de 2002). «Nucleolin associates with a subset of the human Ro ribonucleoprotein complexes». J. Mol. Biol. (England) 320 (3): 475-88. ISSN 0022-2836. PMID 12096904.

[pmid9512561-8] Haluska, P; Saleem A, Edwards T K, Rubin E H (Apr. de 1998). «Interaction between the N-terminus of human topoisomerase I and SV40 large T antigen». Nucleic Acids Res. (ENGLAND) 26 (7): 1841-7. ISSN 0305-1048. PMID 9512561.

[pmid8567649-9] Bharti, A K; Olson M O, Kufe D W, Rubin E H (Jan. de 1996). «Identification of a nucleolin binding site in human topoisomerase I». J. Biol. Chem. (UNITED STATES) 271 (4): 1993-7. ISSN 0021-9258. PMID 8567649.

[pmid12138209-10] Daniely, Yaron; Dimitrova Diana D, Borowiec James A (Aug. de 2002). «Stress-dependent nucleolin mobilization mediated by p53-nucleolin complex formation». Mol. Cell. Biol. (United States) 22 (16): 6014-22. ISSN 0270-7306. PMID 12138209.

[pmid14623863-11] Sakaguchi, Masakiyo; Miyazaki Masahiro, Takaishi Mikiro, Sakaguchi Yoshihiko, Makino Eiichi, Kataoka Noriyuki, Yamada Hidenori, Namba Masayoshi, Huh Nam-ho (Nov. de 2003). «S100C/A11 is a key mediator of Ca(2+)-induced growth inhibition of human epidermal keratinocytes». J. Cell Biol. (United States) 163 (4): 825-35. ISSN 0021-9525. PMID 14623863. doi:10.1083/jcb.200304017.

[pmid8620867-12] Li, Y P; Busch R K, Valdez B C, Busch H (Apr. de 1996). «C23 interacts with B23, a putative nucleolar-localization-signal-binding protein». Eur. J. Biochem. (GERMANY) 237 (1): 153-8. ISSN 0014-2956. PMID 8620867.

[pmid15371412-13] Khurts, Shilagardi; Masutomi Kenkichi, Delgermaa Luvsanjav, Arai Kuniaki, Oishi Naoki, Mizuno Hideki, Hayashi Naoyuki, Hahn William C, Murakami Seishi (Dec. de 2004). «Nucleolin interacts with telomerase». J. Biol. Chem. (United States) 279 (49): 51508-15. ISSN 0021-9258. PMID 15371412. doi:10.1074/jbc.M407643200.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

[12]

[13]

Summary

Interacciones

Referencias