Hamilton nació en Topeka, Kansas en 1880. (Su año de nacimiento figura a veces como 1879 o 1883).

El debut de Hamilton en Broadway fue en Don Caesar's Return (1901).^[2]​

Estuvo casado con tres actrices, Jane Oaker, Myrtle Tannehill y Grace La Rue. Tannehill demandó a Hamilton, acusándolo de haber sido atraído por La Rue.^[3]​

Murió de una hemorragia cerebral en 1942 en Hollywood, California.^{[cita requerida]}

• Her Painted Hero (1915, cortometraje) - Un ídolo de la matiné
• The Winning of Beatrice (1918) - Robert Howard
• Opportunity (1918) - Anthony Fry
• Five Thousand an Hour (1918) - Johnny Gamble
• The Return of Mary (1918, escritor)
• Johnny-on-the-Spot (1919) - Johnny Rutledge
• That's Good (1919) (juntó con Grace La Rue) - Marcellus Starr
• After His Own Heart (1919) - Thomas Wentworth Duncan
• Full of Pep (1919) - Jimmy Baxter
• In His Brother's Place (1919) - Nelson Drake / J. Barrington Drake
• The Four-Flusher (1919) - Lon Withers
• His Children's Children (1923) - Rufus Kayne
• The Manicure Girl (1925) - James Morgan
• The Greater Glory (1926) - Leon Krum
• The Great Gatsby (1926) - Tom Buchanan
• Tin Gods (1926) - Dr. McCoy
• Summer Bachelors (1926) - Beverly Greenway
• Girl in the Rain (1927)
• The Telephone Girl (1927) - Mark
• Good Intentions (1930) - Franklin Graham
• Common Clay (1930) - Judge Samuel Filson
• Paid (1930) - District Attorney Demarest
• Beau Ideal (1931) - Maj. LeBaudy
• Dance, Fools, Dance (1931) - Mr. Selby
• The Drums of Jeopardy (1931) - Martin Kent
• A Tailor Made Man (1931) - Mr. Stanlaw
• Strangers May Kiss (1931) - Andrew
• Never the Twain Shall Meet (1931) - Mark Mellenger
• The Great Lover (1931) - Stapleton
• Rebound (1931) - Lyman Patterson
• Murder at Midnight (1931) - Phillip Montrose
• New Adventures of Get Rich Quick Wallingford (1931) - Charles Harper
• Susan Lenox (Her Fall and Rise) (1931) - Mike Kelly
• The Champ (1931) - Tony Carleton
• The Cuban Love Song (1931) - John
• A Fool's Advice (1932) - George Diamond
• Love Affair (1932) - Bruce Hardy
• Two Against the World (1932) - Mr. Gordon Mitchell
• Life Begins (1932) - Dr. Cramm
• Those We Love (1932) - Blake
• The Most Dangerous Game (1932) - Bill - propietario de Yacht (sin acreditar)
• A Successful Calamity (1932) - John Belde - asociado comercial de Wilton
• Three on a Match (1932) - Defense Attorney
• I Am a Fugitive from a Chain Gang (1932) - Rev. Robert Allen
• Call Her Savage (1932) - Cyrus Randall (uncredited)
• Manhattan Tower (1932) - David Witman
• The Billion Dollar Scandal (1933) - Jackson
• Employees' Entrance (1933) - Monroe
• Reform Girl (1933) - Santor Putnam
• Parole Girl (1933) - Anthony 'Tony' Grattan
• Black Beauty (1933) - Harlan Bledsoe
• Strange People (1933) - J.E.Burton - the Attorney
• One Man's Journey (1933) - Dr. Tillinghast
• The Wolf Dog (1933, Serial) - Norman Bryan
• Curtain at Eight (1933) - Major Manning
• Sitting Pretty (1933) - Vinton (sin acreditar)
• Twin Husbands (1933) - Colonel Gordon Lewis
• The Quitter (1934) - Maj. Stephen Winthrop
• City Park (1934) - Herbert Ransome
• Private Scandal (1934) - Jim Orrington (sin acreditar)
• Dr. Monica (1934) - Dr. Brent
• The Girl from Missouri (1934) - Charlie Turner
• Big Hearted Herbert (1934) - Mr. Havens
• When Strangers Meet (1934) - Captain Manning
• The Marines Are Coming (1934) - Colonel Gilroy
• Grand Old Girl (1935) - Killaine
• After Office Hours (1935) - Henry King Patterson
• The Woman in Red (1935) - Wyatt Furness
• Hold 'Em Yale (1935) - Mr. Wilmot
• Let 'Em Have It (1935) - Exsenador Reilly
• The Nitwits (1935) - Winfield Lake
• Calm Yourself (1935) - Mr. M.B. Kent
• Dante's Inferno (1935) - Mr. Wallace (sin acreditar)
• I Live My Life (1935) - Tío Carl
• Three Kids and a Queen (1935) - Ralph
• The Adventures of Marco Polo (1938) - Maffeo Polo (sin acreditar)
• Edison, the Man (1940) - Broker (sin acreditar) (último papel cinematográfico)

•   Wikimedia Commons alberga una categoría multimedia sobre Hale Hamilton.
• Hale Hamilton en Internet Movie Database (en inglés).
• Hale Hamilton en Internet Broadway Database (en inglés)
• Portrait 1930 (University of Washington, Sayre)