BUB1B Knowpia

Serina/treonina cinasa de punto de control mitótico BUB1 beta
Estructuras disponibles
PDB	Buscar ortólogos: PDBe, RCSB Estructuras enzimáticas RCSB PDB, PDBe, PDBsum
Identificadores
Nomenclatura	Otros nombres Quinasa de punto de control mitótico MAD3L
Símbolo	hBUBR1 (HGNC: 1149)
Identificadores; externos	OMIM: 602860 ; EBI: hBUBR1; GeneCards: Gen hBUBR1; UniProt: hBUBR1; Bases de datos de enzimas IntEnz: entrada en IntEnz; BRENDA: entrada en BRENDA; ExPASy: NiceZime view; KEGG: entrada en KEEG; PRIAM: perfil PRIAM; ExplorEnz: entrada en ExplorEnz; MetaCyc: vía metabólica
Número EC	2.7.11.1
Locus	Cr. 15 q15
	Referencias: AmiGO / QuickGO
Estructura/Función proteica
Tamaño	1050 (aminoácidos)
Ortólogos
Humano	Ratón
701
O60566	n/a
NM_001211	n/a
[1] ;
[2]
	v; t; e;
	[editar datos en Wikidata]

La serina/treonina cinasa de punto de control mitótico BUB1 beta (BUB1B) es una enzima codificada en humanos por el gen HGNC BUB1B .

Este gen codifica una cinasa implicada en la función del punto de control de la mitosis o del ensamblaje del huso mitótico. Esta proteína ha sido localizada en el cinetocoro y juega un importante papel en la inhibición del complejo promotor de la anafase/ciclosoma (APC/C), retrasando la entrada en anafase y asegurando una correcta segregación de los cromosomas. Se has asociado diversos tipos de cáncer con anomalías encontradas en la función del punto de control del huso mitótico.^[1]

Esta enzima pertenece a la familia de las serina/treonina proteína cinasas no específicas (EC 2.7.11.1).

Interacciones

La proteína BUB1B ha demostrado ser capaz de interaccionar con:

AP2B1^[2]
HDAC1^[3]
BUB3^[2]^[4]^[5]
MAD2L1^[4]
Sinucleína gamma^[6]
BRCA2^[7]
CDC20^[4]^[8]^[9]^[10]^[11]^[12]

Referencias

↑ «Entrez Gene: BUB1B BUB1 budding uninhibited by benzimidazoles 1 homolog beta (yeast)».
↑ ^a ^b Cayrol, Corinne; Cougoule Céline, Wright Michel (Nov. de 2002). «The beta2-adaptin clathrin adaptor interacts with the mitotic checkpoint kinase BubR1». Biochem. Biophys. Res. Commun. (United States) 298 (5): 720-30. ISSN 0006-291X. PMID 12419313.
↑ Yoon, Young-Mee; Baek Kwan-Hyuck, Jeong Sook-Jung, Shin Hyun-Jin, Ha Geun-Hyoung, Jeon Ae-Hwa, Hwang Sang-Gu, Chun Jang-Soo, Lee Chang-Woo (Sep. de 2004). «WD repeat-containing mitotic checkpoint proteins act as transcriptional repressors during interphase». FEBS Lett. (Netherlands) 575 (1-3): 23-9. ISSN 0014-5793. PMID 15388328. doi:10.1016/j.febslet.2004.07.089.
↑ ^a ^b ^c Sudakin, V; Chan G K, Yen T J (Sep. de 2001). «Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1, BUB3, CDC20, and MAD2». J. Cell Biol. (United States) 154 (5): 925-36. ISSN 0021-9525. PMID 11535614. doi:10.1083/jcb.200102093.
↑ Taylor, S S; Ha E, McKeon F (Jul. de 1998). «The human homologue of Bub3 is required for kinetochore localization of Bub1 and a Mad3/Bub1-related protein kinase». J. Cell Biol. (UNITED STATES) 142 (1): 1-11. ISSN 0021-9525. PMID 9660858.
↑ Gupta, Anu; Inaba Satoru, Wong Oi Kwan, Fang Guowei, Liu Jingwen (Oct. de 2003). «Breast cancer-specific gene 1 interacts with the mitotic checkpoint kinase BubR1». Oncogene (England) 22 (48): 7593-9. ISSN 0950-9232. PMID 14576821. doi:10.1038/sj.onc.1206880.
↑ Futamura, M; Arakawa H; Matsuda K; Katagiri T; Saji S; Miki Y; Nakamura Y (Mar. de 2000). «Potential role of BRCA2 in a mitotic checkpoint after phosphorylation by hBUBR1». Cancer Res. (UNITED STATES) 60 (6): 1531-5. ISSN 0008-5472. PMID 10749118.
↑ Fang, Guowei (Mar. de 2002). «Checkpoint protein BubR1 acts synergistically with Mad2 to inhibit anaphase-promoting complex». Mol. Biol. Cell (United States) 13 (3): 755-66. ISSN 1059-1524. PMID 11907259. doi:10.1091/mbc.01-09-0437.
↑ Wu, H; Lan Z, Li W, Wu S, Weinstein J, Sakamoto K M, Dai W (Sep. de 2000). «p55CDC/hCDC20 is associated with BUBR1 and may be a downstream target of the spindle checkpoint kinase». Oncogene (ENGLAND) 19 (40): 4557-62. ISSN 0950-9232. PMID 11030144. doi:10.1038/sj.onc.1203803.
↑ Kallio, Marko J; Beardmore Victoria A, Weinstein Jasminder, Gorbsky Gary J (Sep. de 2002). «Rapid microtubule-independent dynamics of Cdc20 at kinetochores and centrosomes in mammalian cells». J. Cell Biol. (United States) 158 (5): 841-7. ISSN 0021-9525. PMID 12196507. doi:10.1083/jcb.200201135.
↑ Skoufias, D A; Andreassen P R, Lacroix F B, Wilson L, Margolis R L (Apr. de 2001). «Mammalian mad2 and bub1/bubR1 recognize distinct spindle-attachment and kinetochore-tension checkpoints». Proc. Natl. Acad. Sci. U.S.A. (United States) 98 (8): 4492-7. ISSN 0027-8424. PMID 11274370. doi:10.1073/pnas.081076898.
↑ Nilsson, Jakob; Yekezare Mona, Minshull Jeremy, Pines Jonathon (Dec. de 2008). «The APC/C maintains the spindle assembly checkpoint by targeting Cdc20 for destruction». Nat. Cell Biol. (England) 10 (12): 1411-20. PMID 19043431. doi:10.1038/ncb1799.

Datos: Q17853927

[entrez-1] «Entrez Gene: BUB1B BUB1 budding uninhibited by benzimidazoles 1 homolog beta (yeast)».

[pmid12419313-2] Cayrol, Corinne; Cougoule Céline, Wright Michel (Nov. de 2002). «The beta2-adaptin clathrin adaptor interacts with the mitotic checkpoint kinase BubR1». Biochem. Biophys. Res. Commun. (United States) 298 (5): 720-30. ISSN 0006-291X. PMID 12419313.

[pmid15388328-3] Yoon, Young-Mee; Baek Kwan-Hyuck, Jeong Sook-Jung, Shin Hyun-Jin, Ha Geun-Hyoung, Jeon Ae-Hwa, Hwang Sang-Gu, Chun Jang-Soo, Lee Chang-Woo (Sep. de 2004). «WD repeat-containing mitotic checkpoint proteins act as transcriptional repressors during interphase». FEBS Lett. (Netherlands) 575 (1-3): 23-9. ISSN 0014-5793. PMID 15388328. doi:10.1016/j.febslet.2004.07.089.

[pmid11535616-4] Sudakin, V; Chan G K, Yen T J (Sep. de 2001). «Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1, BUB3, CDC20, and MAD2». J. Cell Biol. (United States) 154 (5): 925-36. ISSN 0021-9525. PMID 11535614. doi:10.1083/jcb.200102093.

[pmid9660858-5] Taylor, S S; Ha E, McKeon F (Jul. de 1998). «The human homologue of Bub3 is required for kinetochore localization of Bub1 and a Mad3/Bub1-related protein kinase». J. Cell Biol. (UNITED STATES) 142 (1): 1-11. ISSN 0021-9525. PMID 9660858.

[pmid14576821-6] Gupta, Anu; Inaba Satoru, Wong Oi Kwan, Fang Guowei, Liu Jingwen (Oct. de 2003). «Breast cancer-specific gene 1 interacts with the mitotic checkpoint kinase BubR1». Oncogene (England) 22 (48): 7593-9. ISSN 0950-9232. PMID 14576821. doi:10.1038/sj.onc.1206880.

[pmid10749118-7] Futamura, M; Arakawa H; Matsuda K; Katagiri T; Saji S; Miki Y; Nakamura Y (Mar. de 2000). «Potential role of BRCA2 in a mitotic checkpoint after phosphorylation by hBUBR1». Cancer Res. (UNITED STATES) 60 (6): 1531-5. ISSN 0008-5472. PMID 10749118.

[pmid11907259-8] Fang, Guowei (Mar. de 2002). «Checkpoint protein BubR1 acts synergistically with Mad2 to inhibit anaphase-promoting complex». Mol. Biol. Cell (United States) 13 (3): 755-66. ISSN 1059-1524. PMID 11907259. doi:10.1091/mbc.01-09-0437.

[pmid11030144-9] Wu, H; Lan Z, Li W, Wu S, Weinstein J, Sakamoto K M, Dai W (Sep. de 2000). «p55CDC/hCDC20 is associated with BUBR1 and may be a downstream target of the spindle checkpoint kinase». Oncogene (ENGLAND) 19 (40): 4557-62. ISSN 0950-9232. PMID 11030144. doi:10.1038/sj.onc.1203803.

[pmid12196507-10] Kallio, Marko J; Beardmore Victoria A, Weinstein Jasminder, Gorbsky Gary J (Sep. de 2002). «Rapid microtubule-independent dynamics of Cdc20 at kinetochores and centrosomes in mammalian cells». J. Cell Biol. (United States) 158 (5): 841-7. ISSN 0021-9525. PMID 12196507. doi:10.1083/jcb.200201135.

[pmid11274370-11] Skoufias, D A; Andreassen P R, Lacroix F B, Wilson L, Margolis R L (Apr. de 2001). «Mammalian mad2 and bub1/bubR1 recognize distinct spindle-attachment and kinetochore-tension checkpoints». Proc. Natl. Acad. Sci. U.S.A. (United States) 98 (8): 4492-7. ISSN 0027-8424. PMID 11274370. doi:10.1073/pnas.081076898.

[pmid18997788-12] Nilsson, Jakob; Yekezare Mona, Minshull Jeremy, Pines Jonathon (Dec. de 2008). «The APC/C maintains the spindle assembly checkpoint by targeting Cdc20 for destruction». Nat. Cell Biol. (England) 10 (12): 1411-20. PMID 19043431. doi:10.1038/ncb1799.

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Summary

Interacciones

Referencias