TH1L Knowpia

Factor de elongación negativa C/D
Estructuras disponibles
PDB	Buscar ortólogos: PDBe, RCSB
Identificadores
Símbolos	TH1L (HGNC: 15934) HSPC130; NELF-C; NELF-D; TH1
Identificadores; externos	OMIM: 605297 ; EBI: TH1L; GeneCards: Gen TH1L; UniProt: TH1L;
Locus	Cr. 20 q13.32
	Referencias: AmiGO / QuickGO
Ortólogos
Humano	Ratón
51497
Q8IXH7	n/a
NP_945327	n/a
	v; t; e;
	[editar datos en Wikidata]

El factor de elongación negativa C/D (TH1L) es una proteína codificada en humanos por el gen TH1L.^[1]^[2]^[3]

El complejo proteico NELF interacciona con el complejo DISF para reprimir el proceso de elongación transcripcional de la ARN polimerasa II. La proteína codificada por este gen es una parte esencial del complejo NELF. Se han descritos diversas variantes transcripcionales de este gen, que codifican dos isoformas de la proteína con diferente extremo N-terminal.^[3]

Interacciones

La proteína TH1L ha demostrado ser capaz de interaccionar con:

Referencias

↑ Bonthron DT, Hayward BE, Moran V, Strain L (Oct de 2000). «Characterization of TH1 and CTSZ, two non-imprinted genes downstream of GNAS1 in chromosome 20q13». Hum Genet 107 (2): 165-75. PMID 11030415.
↑ Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z (Nov de 2000). «Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells». Genome Res 10 (10): 1546-60. PMC 310934. PMID 11042152.
↑ ^a ^b «Entrez Gene: TH1L TH1-like (Drosophila)».
↑ ^a ^b Ewing, Rob M; Chu Peter, Elisma Fred, Li Hongyan, Taylor Paul, Climie Shane, McBroom-Cerajewski Linda, Robinson Mark D, O'Connor Liam, Li Michael, Taylor Rod, Dharsee Moyez, Ho Yuen, Heilbut Adrian, Moore Lynda, Zhang Shudong, Ornatsky Olga, Bukhman Yury V, Ethier Martin, Sheng Yinglun, Vasilescu Julian, Abu-Farha Mohamed, Lambert Jean-Philippe, Duewel Henry S, Stewart Ian I, Kuehl Bonnie, Hogue Kelly, Colwill Karen, Gladwish Katharine, Muskat Brenda, Kinach Robert, Adams Sally-Lin, Moran Michael F, Morin Gregg B, Topaloglou Thodoros, Figeys Daniel (2007). «Large-scale mapping of human protein-protein interactions by mass spectrometry». Mol. Syst. Biol. (England) 3: 89. PMID 17353931. doi:10.1038/msb4100134.
↑ ^a ^b Narita, Takashi; Yamaguchi Yuki, Yano Keiichi, Sugimoto Seiji, Chanarat Sittinan, Wada Tadashi, Kim Dong-ki, Hasegawa Jun, Omori Masashi, Inukai Naoto, Endoh Masaki, Yamada Tomoko, Handa Hiroshi (Mar. de 2003). «Human transcription elongation factor NELF: identification of novel subunits and reconstitution of the functionally active complex». Mol. Cell. Biol. (United States) 23 (6): 1863-73. ISSN 0270-7306. PMID 12612062.
↑ Yuryev, Anton; Wennogle Lawrence P (Feb. de 2003). «Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid analysis». Genomics (United States) 81 (2): 112-25. ISSN 0888-7543. PMID 12620389.
↑ Yin, Xiang L; Chen She, Gu Jian X (Feb. de 2002). «Identification of TH1 as an interaction partner of A-Raf kinase». Mol. Cell. Biochem. (Netherlands) 231 (1-2): 69-74. ISSN 0300-8177. PMID 11952167.

Datos: Q18040324

[pmid11030415-1] Bonthron DT, Hayward BE, Moran V, Strain L (Oct de 2000). «Characterization of TH1 and CTSZ, two non-imprinted genes downstream of GNAS1 in chromosome 20q13». Hum Genet 107 (2): 165-75. PMID 11030415.

[pmid11042152-2] Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z (Nov de 2000). «Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells». Genome Res 10 (10): 1546-60. PMC 310934. PMID 11042152.

[entrez-3] «Entrez Gene: TH1L TH1-like (Drosophila)».

[pmid17353931-4] Ewing, Rob M; Chu Peter, Elisma Fred, Li Hongyan, Taylor Paul, Climie Shane, McBroom-Cerajewski Linda, Robinson Mark D, O'Connor Liam, Li Michael, Taylor Rod, Dharsee Moyez, Ho Yuen, Heilbut Adrian, Moore Lynda, Zhang Shudong, Ornatsky Olga, Bukhman Yury V, Ethier Martin, Sheng Yinglun, Vasilescu Julian, Abu-Farha Mohamed, Lambert Jean-Philippe, Duewel Henry S, Stewart Ian I, Kuehl Bonnie, Hogue Kelly, Colwill Karen, Gladwish Katharine, Muskat Brenda, Kinach Robert, Adams Sally-Lin, Moran Michael F, Morin Gregg B, Topaloglou Thodoros, Figeys Daniel (2007). «Large-scale mapping of human protein-protein interactions by mass spectrometry». Mol. Syst. Biol. (England) 3: 89. PMID 17353931. doi:10.1038/msb4100134.

[pmid12612062-5] Narita, Takashi; Yamaguchi Yuki, Yano Keiichi, Sugimoto Seiji, Chanarat Sittinan, Wada Tadashi, Kim Dong-ki, Hasegawa Jun, Omori Masashi, Inukai Naoto, Endoh Masaki, Yamada Tomoko, Handa Hiroshi (Mar. de 2003). «Human transcription elongation factor NELF: identification of novel subunits and reconstitution of the functionally active complex». Mol. Cell. Biol. (United States) 23 (6): 1863-73. ISSN 0270-7306. PMID 12612062.

[pmid12620389-6] Yuryev, Anton; Wennogle Lawrence P (Feb. de 2003). «Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid analysis». Genomics (United States) 81 (2): 112-25. ISSN 0888-7543. PMID 12620389.

[pmid11952167-7] Yin, Xiang L; Chen She, Gu Jian X (Feb. de 2002). «Identification of TH1 as an interaction partner of A-Raf kinase». Mol. Cell. Biochem. (Netherlands) 231 (1-2): 69-74. ISSN 0300-8177. PMID 11952167.

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Summary

Interacciones

Referencias