RPA2 Knowpia

Subunidad de 32 kDa de la proteína A de replicación
	; Estructura tridimensional de la proteína RPA2.
Estructuras disponibles
PDB	Buscar ortólogos: PDBe, RCSB Lista de códigos PDB 1dpu
Identificadores
Símbolos	RPA2 (HGNC: 10290) REPA2; RPA32
Identificadores; externos	OMIM: 179836 ; EBI: RPA2; GeneCards: Gen RPA2; UniProt: RPA2;
Locus	Cr. 1 p35.3
	Referencias: AmiGO / QuickGO
Ortólogos
Humano	Ratón
6118
P15927	n/a
NP_002937	n/a
	v; t; e;
	[editar datos en Wikidata]

La subunidad de 32 kDa de la proteína A de replicación (RPA2) es una proteína codificada en humanos por el gen rpa2.^[1]^[2]

Interacciones

La proteína RPA2 ha demostrado ser capaz de interaccionar con:

Ku70^[3]
Proteína de replicación A1^[3]^[4]
RPA3^[5]^[4]
DNA-PKcs^[3]
STAT3^[6]
Ciclina O^[7]
MEN1^[8]
TP53BP1^[9]
Uracil-ADN glicosilasa^[10]

Referencias

↑ Umbricht CB, Erdile LF, Jabs EW, Kelly TJ (Apr de 1993). «Cloning, overexpression, and genomic mapping of the 14-kDa subunit of human replication protein A». J Biol Chem 268 (9): 6131-8. PMID 8454588.
↑ «Entrez Gene: RPA2 Replication protein A2, 32kDa».
↑ ^a ^b ^c Shao, R G; Cao C X, Zhang H, Kohn K W, Wold M S, Pommier Y (Mar. de 1999). «Replication-mediated DNA damage by camptothecin induces phosphorylation of RPA by DNA-dependent protein kinase and dissociates RPA:DNA-PK complexes». EMBO J. (ENGLAND) 18 (5): 1397-406. ISSN 0261-4189. PMID 10064605. doi:10.1093/emboj/18.5.1397.
↑ ^a ^b Bochkareva, Elena; Korolev Sergey, Lees-Miller Susan P, Bochkarev Alexey (Apr. de 2002). «Structure of the RPA trimerization core and its role in the multistep DNA-binding mechanism of RPA». EMBO J. (England) 21 (7): 1855-63. ISSN 0261-4189. PMID 11927569. doi:10.1093/emboj/21.7.1855.
↑ Bochkareva, E; Frappier L, Edwards A M, Bochkarev A (Feb. de 1998). «The RPA32 subunit of human replication protein A contains a single-stranded DNA-binding domain». J. Biol. Chem. (UNITED STATES) 273 (7): 3932-6. ISSN 0021-9258. PMID 9461578.
↑ Kim, J; Kim D; Chung J (2000). «Replication protein a 32 kDa subunit (RPA p32) binds the SH2 domain of STAT3 and regulates its transcriptional activity». Cell Biol. Int. (ENGLAND) 24 (7): 467-73. ISSN 1065-6995. PMID 10875894. doi:10.1006/cbir.2000.0525.
↑ Otterlei, M; Warbrick E, Nagelhus T A, Haug T, Slupphaug G, Akbari M, Aas P A, Steinsbekk K, Bakke O, Krokan H E (Jul. de 1999). «Post-replicative base excision repair in replication foci». EMBO J. (ENGLAND) 18 (13): 3834-44. ISSN 0261-4189. PMID 10393198. doi:10.1093/emboj/18.13.3834.
↑ Sukhodolets, Karen E; Hickman Alison B, Agarwal Sunita K, Sukhodolets Maxim V, Obungu Victor H, Novotny Elizabeth A, Crabtree Judy S, Chandrasekharappa Settara C, Collins Francis S, Spiegel Allen M, Burns A Lee, Marx Stephen J (Jan. de 2003). «The 32-kilodalton subunit of replication protein A interacts with menin, the product of the MEN1 tumor suppressor gene». Mol. Cell. Biol. (United States) 23 (2): 493-509. ISSN 0270-7306. PMID 12509449.
↑ Yoo, Eunjae; Kim Byung U, Lee Seung Youn, Cho Chae Hyun, Chung Jay H, Lee Chang-Hun (Aug. de 2005). «53BP1 is associated with replication protein A and is required for RPA2 hyperphosphorylation following DNA damage». Oncogene (England) 24 (35): 5423-30. ISSN 0950-9232. PMID 15856006. doi:10.1038/sj.onc.1208710.
↑ Nagelhus, T A; Haug T, Singh K K, Keshav K F, Skorpen F, Otterlei M, Bharati S, Lindmo T, Benichou S, Benarous R, Krokan H E (Mar. de 1997). «A sequence in the N-terminal region of human uracil-DNA glycosylase with homology to XPA interacts with the C-terminal part of the 34-kDa subunit of replication protein A». J. Biol. Chem. (UNITED STATES) 272 (10): 6561-6. ISSN 0021-9258. PMID 9045683.

Datos: Q18031220

[pmid8454588-1] Umbricht CB, Erdile LF, Jabs EW, Kelly TJ (Apr de 1993). «Cloning, overexpression, and genomic mapping of the 14-kDa subunit of human replication protein A». J Biol Chem 268 (9): 6131-8. PMID 8454588.

[2] «Entrez Gene: RPA2 Replication protein A2, 32kDa».

[pmid10064605-3] Shao, R G; Cao C X, Zhang H, Kohn K W, Wold M S, Pommier Y (Mar. de 1999). «Replication-mediated DNA damage by camptothecin induces phosphorylation of RPA by DNA-dependent protein kinase and dissociates RPA:DNA-PK complexes». EMBO J. (ENGLAND) 18 (5): 1397-406. ISSN 0261-4189. PMID 10064605. doi:10.1093/emboj/18.5.1397.

[pmid11927569-4] Bochkareva, Elena; Korolev Sergey, Lees-Miller Susan P, Bochkarev Alexey (Apr. de 2002). «Structure of the RPA trimerization core and its role in the multistep DNA-binding mechanism of RPA». EMBO J. (England) 21 (7): 1855-63. ISSN 0261-4189. PMID 11927569. doi:10.1093/emboj/21.7.1855.

[pmid9461578-5] Bochkareva, E; Frappier L, Edwards A M, Bochkarev A (Feb. de 1998). «The RPA32 subunit of human replication protein A contains a single-stranded DNA-binding domain». J. Biol. Chem. (UNITED STATES) 273 (7): 3932-6. ISSN 0021-9258. PMID 9461578.

[pmid10875894-6] Kim, J; Kim D; Chung J (2000). «Replication protein a 32 kDa subunit (RPA p32) binds the SH2 domain of STAT3 and regulates its transcriptional activity». Cell Biol. Int. (ENGLAND) 24 (7): 467-73. ISSN 1065-6995. PMID 10875894. doi:10.1006/cbir.2000.0525.

[pmid10393198-7] Otterlei, M; Warbrick E, Nagelhus T A, Haug T, Slupphaug G, Akbari M, Aas P A, Steinsbekk K, Bakke O, Krokan H E (Jul. de 1999). «Post-replicative base excision repair in replication foci». EMBO J. (ENGLAND) 18 (13): 3834-44. ISSN 0261-4189. PMID 10393198. doi:10.1093/emboj/18.13.3834.

[pmid12509449-8] Sukhodolets, Karen E; Hickman Alison B, Agarwal Sunita K, Sukhodolets Maxim V, Obungu Victor H, Novotny Elizabeth A, Crabtree Judy S, Chandrasekharappa Settara C, Collins Francis S, Spiegel Allen M, Burns A Lee, Marx Stephen J (Jan. de 2003). «The 32-kilodalton subunit of replication protein A interacts with menin, the product of the MEN1 tumor suppressor gene». Mol. Cell. Biol. (United States) 23 (2): 493-509. ISSN 0270-7306. PMID 12509449.

[pmid15856006-9] Yoo, Eunjae; Kim Byung U, Lee Seung Youn, Cho Chae Hyun, Chung Jay H, Lee Chang-Hun (Aug. de 2005). «53BP1 is associated with replication protein A and is required for RPA2 hyperphosphorylation following DNA damage». Oncogene (England) 24 (35): 5423-30. ISSN 0950-9232. PMID 15856006. doi:10.1038/sj.onc.1208710.

[pmid9045683-10] Nagelhus, T A; Haug T, Singh K K, Keshav K F, Skorpen F, Otterlei M, Bharati S, Lindmo T, Benichou S, Benarous R, Krokan H E (Mar. de 1997). «A sequence in the N-terminal region of human uracil-DNA glycosylase with homology to XPA interacts with the C-terminal part of the 34-kDa subunit of replication protein A». J. Biol. Chem. (UNITED STATES) 272 (10): 6561-6. ISSN 0021-9258. PMID 9045683.

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Summary

Interacciones

Referencias