RFWD2 Knowpia

COP1
Estructuras disponibles
PDB	Búsqueda ortóloga: PDBe RCSB
Lista de codigos id de PDB
	5IGQ, 5HQG
Identificadores
Alias	COP1, RNF200, ring finger and WD repeat domain 2, E3 ubiquitin ligase, RFWD2, COP1 E3 ubiquitin ligase, FAP78, CFAP78
IDs externos	OMIM: 608067 MGI: 1347046 HomoloGene: 115565 GeneCards: COP1
Ontología génica
Función molecular	• GO:0001948, GO:0016582 unión a proteína plasmática; • metal ion binding; • GO:0050372 ubiquitin-protein transferase activity; • transferase activity; • GO:1904264, GO:1904822, GO:0090622, GO:0090302 ubiquitin protein ligase activity; • zinc ion binding;
Componente celular	• nuclear speck; • citosol; • Golgi membrane; • núcleo celular; • citoplasma; • Nucleoplasma; • Cul4A-RING E3 ubiquitin ligase complex; • centrosoma; • focal adhesion;
Proceso biológico	• ubicuitinación de proteínas; • response to ionizing radiation; • positive regulation of proteasomal ubiquitin-dependent protein catabolic process; • modificación postraduccional; • proteasome-mediated ubiquitin-dependent protein catabolic process;
	Fuentes: Amigo / QuickGO
Ortólogos
	64326
	26374
	ENSG00000143207
	ENSMUSG00000040782
	Q8NHY2
	Q9R1A8
	NM_001001740; NM_001286644; NM_022457
	NM_011931; NM_001360878
	NP_001001740; NP_001273573; NP_071902
	NP_036061; NP_001347807
	Wikidata
Ver/Editar Humano	Ver/Editar Ratón

La ubiquitina proteína ligasa E3 RFWD2 (RFWD2 de sus siglas en inglés "Ring finger and WD repeat domain 2") es una enzima codificada en humanos por el gen RFWD2.^[3]^[4]

Interacciones

La proteína RFWD2 ha demostrado ser capaz de interaccionar con:

c-Jun^[5]^[6]

Referencias

↑ «Human PubMed Reference:».
↑ «Mouse PubMed Reference:».
↑ Wang H, Kang D, Deng XW, Wei N (Sep de 1999). «Evidence for functional conservation of a mammalian homologue of the light-responsive plant protein COP1». Curr Biol 9 (13): 711-4. PMID 10395541.
↑ «Entrez Gene: RFWD2 ring finger and WD repeat domain 2».
↑ Wertz, Ingrid E; O'Rourke Karen M, Zhang Zemin, Dornan David, Arnott David, Deshaies Raymond J, Dixit Vishva M (Feb. de 2004). «Human De-etiolated-1 regulates c-Jun by assembling a CUL4A ubiquitin ligase». Science (United States) 303 (5662): 1371-4. PMID 14739464. doi:10.1126/science.1093549.
↑ Bianchi, Elisabetta; Denti Simona, Catena Raffaella, Rossetti Grazisa, Polo Simona, Gasparian Sona, Putignano Stella, Rogge Lars, Pardi Ruggero (mayo. de 2003). «Characterization of human constitutive photomorphogenesis protein 1, a RING finger ubiquitin ligase that interacts with Jun transcription factors and modulates their transcriptional activity». J. Biol. Chem. (United States) 278 (22): 19682-90. ISSN 0021-9258. PMID 12615916. doi:10.1074/jbc.M212681200.

Datos: Q18045635

[1] «Human PubMed Reference:».

[2] «Mouse PubMed Reference:».

[pmid10395541-3] Wang H, Kang D, Deng XW, Wei N (Sep de 1999). «Evidence for functional conservation of a mammalian homologue of the light-responsive plant protein COP1». Curr Biol 9 (13): 711-4. PMID 10395541.

[entrez-4] «Entrez Gene: RFWD2 ring finger and WD repeat domain 2».

[pmid14739464-5] Wertz, Ingrid E; O'Rourke Karen M, Zhang Zemin, Dornan David, Arnott David, Deshaies Raymond J, Dixit Vishva M (Feb. de 2004). «Human De-etiolated-1 regulates c-Jun by assembling a CUL4A ubiquitin ligase». Science (United States) 303 (5662): 1371-4. PMID 14739464. doi:10.1126/science.1093549.

[pmid12615916-6] Bianchi, Elisabetta; Denti Simona, Catena Raffaella, Rossetti Grazisa, Polo Simona, Gasparian Sona, Putignano Stella, Rogge Lars, Pardi Ruggero (mayo. de 2003). «Characterization of human constitutive photomorphogenesis protein 1, a RING finger ubiquitin ligase that interacts with Jun transcription factors and modulates their transcriptional activity». J. Biol. Chem. (United States) 278 (22): 19682-90. ISSN 0021-9258. PMID 12615916. doi:10.1074/jbc.M212681200.

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Summary

Interacciones

Referencias