POLR2C Knowpia

Subunidad RPB3 de la ARN polimerasa II
Estructuras disponibles
PDB	Buscar ortólogos: PDBe, RCSB
Identificadores
Símbolos	POLR2C (HGNC: 9189) RPB3, RPB31, hRPB33, hsRPB3
Identificadores; externos	OMIM: 180663 ; EBI: POLR2C; GeneCards: Gen POLR2C; UniProt: POLR2C;
Locus	Cr. 16 q13
	Referencias: AmiGO / QuickGO
Ortólogos
Humano	Ratón
5432
P19387	n/a
NP_116558	n/a
	v; t; e;
	[editar datos en Wikidata]

La subunidad RPB3 de la ARN polimerasa II (POLR2C) es una enzima codificada en humanos por el gen polr2C.^[1]

Esta proteína es la tercera subunidad más larga de la ARN polimerasa II, la polimerasa responsable de la síntesis del ARNm en eucariotas. POLR2C presenta una región rica en cisteínas y existe en forma de heterodímero con otra subunidad de la polimerasa, POLR2J. Estas dos subunidades forman una unidad de ensamblaje de la polimerasa. Se ha descrito un pseudogén de polr2C en el cromosoma 21.^[2]

Interacciones

La proteína POLR2C ha demostrado ser capaz de interaccionar con:

TAF15^[3]
POLR2F^[4]
POLR2G^[4]
POLR2H^[4]
POLR2J^[4]^[5]
POLR2K^[4]
POLR2L^[4]
ATF4^[6]
CCHCR1^[7]
POLR2A^[4]
POLR2B^[4]
POLR2E^[4]
Miogenina^[5]

Referencias

↑ Acker J, Mattei MG, Wintzerith M, Roeckel N, Depetris D, Vigneron M, Kedinger C (Aug de 1994). «Chromosomal localization of human RNA polymerase II subunit genes». Genomics 20 (3): 496-9. PMID 8034326. doi:10.1006/geno.1994.1208.
↑ «Entrez Gene: POLR2C polymerase (RNA) II (DNA directed) polypeptide C, 33kDa».
↑ Bertolotti, A; Melot T; Acker J; Vigneron M; Delattre O; Tora L (Mar. de 1998). «EWS, but not EWS-FLI-1, is associated with both TFIID and RNA polymerase II: interactions between two members of the TET family, EWS and hTAFII68, and subunits of TFIID and RNA polymerase II complexes». Mol. Cell. Biol. (UNITED STATES) 18 (3): 1489-97. ISSN 0270-7306. PMID 9488465.
↑ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ Acker, J; de Graaff M, Cheynel I, Khazak V, Kedinger C, Vigneron M (Jul. de 1997). «Interactions between the human RNA polymerase II subunits». J. Biol. Chem. (UNITED STATES) 272 (27): 16815-21. ISSN 0021-9258. PMID 9201987.
↑ ^a ^b Corbi, Nicoletta; Di Padova Monica, De Angelis Roberta, Bruno Tiziana, Libri Valentina, Iezzi Simona, Floridi Aristide, Fanciulli Maurizio, Passananti Claudio (Oct. de 2002). «The alpha-like RNA polymerase II core subunit 3 (RPB3) is involved in tissue-specific transcription and muscle differentiation via interaction with the myogenic factor myogenin». FASEB J. (United States) 16 (12): 1639-41. PMID 12207009. doi:10.1096/fj.02-0123fje.
↑ De Angelis, Roberta; Iezzi Simona, Bruno Tiziana, Corbi Nicoletta, Di Padova Monica, Floridi Aristide, Fanciulli Maurizio, Passananti Claudio (Jul. de 2003). «Functional interaction of the subunit 3 of RNA polymerase II (RPB3) with transcription factor-4 (ATF4)». FEBS Lett. (Netherlands) 547 (1-3): 15-9. ISSN 0014-5793. PMID 12860379.
↑ Corbi, Nicoletta; Bruno Tiziana, De Angelis Roberta, Di Padova Monica, Libri Valentina, Di Certo Maria Grazia, Spinardi Laura, Floridi Aristide, Fanciulli Maurizio, Passananti Claudio (Sep. de 2005). «RNA polymerase II subunit 3 is retained in the cytoplasm by its interaction with HCR, the psoriasis vulgaris candidate gene product». J. Cell. Sci. (England) 118 (Pt 18): 4253-60. ISSN 0021-9533. PMID 16141233. doi:10.1242/jcs.02545.

Datos: Q18030649

[pmid8034326-1] Acker J, Mattei MG, Wintzerith M, Roeckel N, Depetris D, Vigneron M, Kedinger C (Aug de 1994). «Chromosomal localization of human RNA polymerase II subunit genes». Genomics 20 (3): 496-9. PMID 8034326. doi:10.1006/geno.1994.1208.

[2] «Entrez Gene: POLR2C polymerase (RNA) II (DNA directed) polypeptide C, 33kDa».

[pmid9488465-3] Bertolotti, A; Melot T; Acker J; Vigneron M; Delattre O; Tora L (Mar. de 1998). «EWS, but not EWS-FLI-1, is associated with both TFIID and RNA polymerase II: interactions between two members of the TET family, EWS and hTAFII68, and subunits of TFIID and RNA polymerase II complexes». Mol. Cell. Biol. (UNITED STATES) 18 (3): 1489-97. ISSN 0270-7306. PMID 9488465.

[pmid9201987-4] ↑ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ Acker, J; de Graaff M, Cheynel I, Khazak V, Kedinger C, Vigneron M (Jul. de 1997). «Interactions between the human RNA polymerase II subunits». J. Biol. Chem. (UNITED STATES) 272 (27): 16815-21. ISSN 0021-9258. PMID 9201987.

[pmid12207009-5] Corbi, Nicoletta; Di Padova Monica, De Angelis Roberta, Bruno Tiziana, Libri Valentina, Iezzi Simona, Floridi Aristide, Fanciulli Maurizio, Passananti Claudio (Oct. de 2002). «The alpha-like RNA polymerase II core subunit 3 (RPB3) is involved in tissue-specific transcription and muscle differentiation via interaction with the myogenic factor myogenin». FASEB J. (United States) 16 (12): 1639-41. PMID 12207009. doi:10.1096/fj.02-0123fje.

[pmid12860379-6] De Angelis, Roberta; Iezzi Simona, Bruno Tiziana, Corbi Nicoletta, Di Padova Monica, Floridi Aristide, Fanciulli Maurizio, Passananti Claudio (Jul. de 2003). «Functional interaction of the subunit 3 of RNA polymerase II (RPB3) with transcription factor-4 (ATF4)». FEBS Lett. (Netherlands) 547 (1-3): 15-9. ISSN 0014-5793. PMID 12860379.

[pmid16141233-7] Corbi, Nicoletta; Bruno Tiziana, De Angelis Roberta, Di Padova Monica, Libri Valentina, Di Certo Maria Grazia, Spinardi Laura, Floridi Aristide, Fanciulli Maurizio, Passananti Claudio (Sep. de 2005). «RNA polymerase II subunit 3 is retained in the cytoplasm by its interaction with HCR, the psoriasis vulgaris candidate gene product». J. Cell. Sci. (England) 118 (Pt 18): 4253-60. ISSN 0021-9533. PMID 16141233. doi:10.1242/jcs.02545.

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Summary

Interacciones

Referencias