ITGB3BP Knowpia

ITGB3BP
Identificadores
Alias	ITGB3BP, CENP-R, CENPR, HSU37139, NRIF3, TAP20, integrin subunit beta 3 binding protein
IDs externos	OMIM: 605494 MGI: 1914983 HomoloGene: 8617 GeneCards: ITGB3BP
Ontología génica
Función molecular	• signal transducer activity; • protein C-terminus binding; • GO:0001948, GO:0016582 unión a proteína plasmática;
Componente celular	• citoplasma; • citosol; • membrana; • Nucleoplasma; • cromosoma; • centrómero; • núcleo celular; • Cinetocoro;
Proceso biológico	• GO:0009373 regulation of transcription, DNA-templated; • GO:0061641 CENP-A containing chromatin assembly; • transcription, DNA-templated; • división celular; • adherencia celular; • positive regulation of apoptotic process; • ciclo celular; • GO:0072468 transducción de señal; • GO:0097285 apoptosis;
	Fuentes: Amigo / QuickGO
Patrón de la expressión del ARN
	Más referencias a datos de expressión
Ortólogos
	23421
	67733
	ENSG00000142856
	ENSMUSG00000028549
	Q13352
	Q9CQ82
	NM_001206739; NM_014288; NM_001347145; NM_001347147; NM_001347148
	NM_026348; NM_001362974; NM_001362975; NM_001362976
	NP_001193668; NP_001334074; NP_001334076; NP_001334077; NP_055103
	NP_080624; NP_001349903; NP_001349904; NP_001349905
	Wikidata
Ver/Editar Humano	Ver/Editar Ratón

La proteína centromérica R (ITGB3BP) es una proteína que es codificada, en humanos, por el gen itgb3BP.^[3]^[4]^[5]

Interacciones

La proteína centromérica R ha demostrado ser capaz de interaccionar con:

Receptor X retinoide gamma^[6]
Ciclina A2^[7]
NFKB1^[8]
Receptor X retinoide alfa^[4]
Receptor de hormona tiroidea alfa^[6]^[4]
CD61^[9]^[3]

Referencias

↑ «Human PubMed Reference:».
↑ «Mouse PubMed Reference:».
↑ ^a ^b Shattil SJ, O'Toole T, Eigenthaler M, Thon V, Williams M, Babior BM, Ginsberg MH (Dec de 1995). «Beta 3-endonexin, a novel polypeptide that interacts specifically with the cytoplasmic tail of the integrin beta 3 subunit». J Cell Biol (Estados Unidos) 131 (3): 807-16. ISSN 0021-9525. PMC 2120613. PMID 7593198.
↑ ^a ^b ^c Li D, Desai-Yajnik V, Lo E, Schapira M, Abagyan R, Samuels HH (Feb de 2000). «NRIF3 is a novel coactivator mediating functional specificity of nuclear hormone receptors». Mol Cell Biol (Estados Unidos) 19 (10): 7191-202. ISSN 0270-7306. PMC 84712. PMID 10490654.
↑ «Entrez Gene: ITGB3BP integrin beta 3 binding protein (beta3-endonexin)».
↑ ^a ^b Li, D; Wang F, Samuels H H (Dec. de 2001). «Domain structure of the NRIF3 family of coregulators suggests potential dual roles in transcriptional regulation». Mol. Cell. Biol. (United States) 21 (24): 8371-84. ISSN 0270-7306. PMID 11713274. doi:10.1128/MCB.21.24.8371-8384.2001.
↑ Ohtoshi, A; Maeda T; Higashi H; Ashizawa S; Yamada M; Hatakeyama M (Jan. de 2000). «beta3-endonexin as a novel inhibitor of cyclin A-associated kinase». Biochem. Biophys. Res. Commun. (UNITED STATES) 267 (3): 947-52. ISSN 0006-291X. PMID 10673397. doi:10.1006/bbrc.1999.2007.
↑ Besta, Felicitas; Massberg Steffen, Brand Korbinian, Müller Elke, Page Sharon, Grüner Sabine, Lorenz Michael, Sadoul Karin, Kolanus Waldemar, Lengyel Ernst, Gawaz Meinrad (Oct. de 2002). «Role of beta(3)-endonexin in the regulation of NF-kappaB-dependent expression of urokinase-type plasminogen activator receptor». J. Cell. Sci. (England) 115 (Pt 20): 3879-88. ISSN 0021-9533. PMID 12244126.
↑ Fujimoto, Tetsuro-Takahiro; Katsutani Shinya, Shimomura Takeshi, Fujimura Kingo (Jan. de 2002). «Novel alternatively spliced form of beta(3)-endonexin». Thromb. Res. (United States) 105 (1): 63-70. ISSN 0049-3848. PMID 11864709.

Datos: Q18037168

[1] «Human PubMed Reference:».

[2] «Mouse PubMed Reference:».

[pmid7593198-3] Shattil SJ, O'Toole T, Eigenthaler M, Thon V, Williams M, Babior BM, Ginsberg MH (Dec de 1995). «Beta 3-endonexin, a novel polypeptide that interacts specifically with the cytoplasmic tail of the integrin beta 3 subunit». J Cell Biol (Estados Unidos) 131 (3): 807-16. ISSN 0021-9525. PMC 2120613. PMID 7593198.

[pmid10490654-4] Li D, Desai-Yajnik V, Lo E, Schapira M, Abagyan R, Samuels HH (Feb de 2000). «NRIF3 is a novel coactivator mediating functional specificity of nuclear hormone receptors». Mol Cell Biol (Estados Unidos) 19 (10): 7191-202. ISSN 0270-7306. PMC 84712. PMID 10490654.

[entrez-5] «Entrez Gene: ITGB3BP integrin beta 3 binding protein (beta3-endonexin)».

[pmid11713274-6] Li, D; Wang F, Samuels H H (Dec. de 2001). «Domain structure of the NRIF3 family of coregulators suggests potential dual roles in transcriptional regulation». Mol. Cell. Biol. (United States) 21 (24): 8371-84. ISSN 0270-7306. PMID 11713274. doi:10.1128/MCB.21.24.8371-8384.2001.

[pmid10673397-7] Ohtoshi, A; Maeda T; Higashi H; Ashizawa S; Yamada M; Hatakeyama M (Jan. de 2000). «beta3-endonexin as a novel inhibitor of cyclin A-associated kinase». Biochem. Biophys. Res. Commun. (UNITED STATES) 267 (3): 947-52. ISSN 0006-291X. PMID 10673397. doi:10.1006/bbrc.1999.2007.

[pmid12244126-8] Besta, Felicitas; Massberg Steffen, Brand Korbinian, Müller Elke, Page Sharon, Grüner Sabine, Lorenz Michael, Sadoul Karin, Kolanus Waldemar, Lengyel Ernst, Gawaz Meinrad (Oct. de 2002). «Role of beta(3)-endonexin in the regulation of NF-kappaB-dependent expression of urokinase-type plasminogen activator receptor». J. Cell. Sci. (England) 115 (Pt 20): 3879-88. ISSN 0021-9533. PMID 12244126.

[pmid11864709-9] Fujimoto, Tetsuro-Takahiro; Katsutani Shinya, Shimomura Takeshi, Fujimura Kingo (Jan. de 2002). «Novel alternatively spliced form of beta(3)-endonexin». Thromb. Res. (United States) 105 (1): 63-70. ISSN 0049-3848. PMID 11864709.

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Summary

Interacciones

Referencias