FHL3 Knowpia

Proteína 3 de cuatro dominios y medio LIM
	; Estructura tridimensional de la proteína FHL3.
Estructuras disponibles
PDB	Buscar ortólogos: PDBe, RCSB Lista de códigos PDB 1WYH , 2CUQ , 2EHE
Identificadores
Símbolos	FHL3 (HGNC: 3704) MGC19547, MGC23614, MGC8696, SLIM2
Identificadores; externos	OMIM: 602790 ; MGI: 1341092 ; HomoloGene: 37928 ; EBI: FHL3; GeneCards: Gen FHL3; UniProt: FHL3;
Locus	Cr. 1 p34.3
	Referencias: AmiGO / QuickGO
Patrón de expresión de ARNm
	Más información
Ortólogos
Humano	Ratón
2275	14201
Véase HS	Véase MM
Q13643	Q9R059
NM_001243878	NM_010213
NP_001230807	NP_034343
Cr. 1:; 38.46 – 38.47 Mb	Cr. 4:; 124.7 – 124.71 Mb
[1] ;	[2]
	v; t; e;
	[editar datos en Wikidata]

La proteína 3 de cuatro dominios y medio LIM (FHL3) es una proteína codificada en humanos por el gen fhl3.^[1]^[2]^[3]

Las proteínas LIM se caracterizan por la posesión de un motivo con dos dedos de zinc altamente conservado, denominado dominio LIM. En el caso de FHL3, esta proteína posee cuatro de estos dominios LIM más un dominio que podría ser la mitad de un dominio LIM.^[3]

Interacciones

La proteína FHL3 ha demostrado ser capaz de interaccionar con:

Referencias

↑ Morgan MJ, Madgwick AJ (Oct de 1996). «Slim defines a novel family of LIM-proteins expressed in skeletal muscle». Biochem Biophys Res Commun 225 (2): 632-8. PMID 8753811. doi:10.1006/bbrc.1996.1222.
↑ Lee SM, Tsui SK, Chan KK, Kotaka M, Li HY, Chim SS, Waye MM, Fung KP, Lee CY (mayo de 1999). «Chromosomal mapping of a skeletal muscle specific LIM-only protein FHL3 to the distal end of the short arm of human chromosome 1». Somat Cell Mol Genet 24 (3): 197-202. PMID 10226657.
↑ ^a ^b «Entrez Gene: FHL3 four and a half LIM domains 3».
↑ ^a ^b Fimia, G M; De Cesare D, Sassone-Corsi P (Nov. de 2000). «A family of LIM-only transcriptional coactivators: tissue-specific expression and selective activation of CREB and CREM». Mol. Cell. Biol. (UNITED STATES) 20 (22): 8613-22. ISSN 0270-7306. PMID 11046156.
↑ Li, H Y; Ng E K, Lee S M, Kotaka M, Tsui S K, Lee C Y, Fung K P, Waye M M (2001). «Protein-protein interaction of FHL3 with FHL2 and visualization of their interaction by green fluorescent proteins (GFP) two-fusion fluorescence resonance energy transfer (FRET)». J. Cell. Biochem. (United States) 80 (3): 293-303. ISSN 0730-2312. PMID 11135358.
↑ ^a ^b Turner, Jeremy; Nicholas Hannah, Bishop David, Matthews Jacqueline M, Crossley Merlin (Apr. de 2003). «The LIM protein FHL3 binds basic Krüppel-like factor/Krüppel-like factor 3 and its co-repressor C-terminal-binding protein 2». J. Biol. Chem. (United States) 278 (15): 12786-95. ISSN 0021-9258. PMID 12556451. doi:10.1074/jbc.M300587200.
↑ Samson, Thomas; Smyth Neil, Janetzky Stefanie, Wendler Olaf, Müller Judith M, Schüle Roland, von der Mark Helga, von der Mark Klaus, Wixler Viktor (Jul. de 2004). «The LIM-only proteins FHL2 and FHL3 interact with alpha- and beta-subunits of the muscle alpha7beta1 integrin receptor». J. Biol. Chem. (United States) 279 (27): 28641-52. ISSN 0021-9258. PMID 15117962. doi:10.1074/jbc.M312894200.

Enlaces externos

MeSH: FHL3+protein,+human (en inglés)

Datos: Q17928418

[pmid8753811-1] Morgan MJ, Madgwick AJ (Oct de 1996). «Slim defines a novel family of LIM-proteins expressed in skeletal muscle». Biochem Biophys Res Commun 225 (2): 632-8. PMID 8753811. doi:10.1006/bbrc.1996.1222.

[pmid10226657-2] Lee SM, Tsui SK, Chan KK, Kotaka M, Li HY, Chim SS, Waye MM, Fung KP, Lee CY (mayo de 1999). «Chromosomal mapping of a skeletal muscle specific LIM-only protein FHL3 to the distal end of the short arm of human chromosome 1». Somat Cell Mol Genet 24 (3): 197-202. PMID 10226657.

[entrez-3] «Entrez Gene: FHL3 four and a half LIM domains 3».

[pmid11046156-4] Fimia, G M; De Cesare D, Sassone-Corsi P (Nov. de 2000). «A family of LIM-only transcriptional coactivators: tissue-specific expression and selective activation of CREB and CREM». Mol. Cell. Biol. (UNITED STATES) 20 (22): 8613-22. ISSN 0270-7306. PMID 11046156.

[pmid11135358-5] Li, H Y; Ng E K, Lee S M, Kotaka M, Tsui S K, Lee C Y, Fung K P, Waye M M (2001). «Protein-protein interaction of FHL3 with FHL2 and visualization of their interaction by green fluorescent proteins (GFP) two-fusion fluorescence resonance energy transfer (FRET)». J. Cell. Biochem. (United States) 80 (3): 293-303. ISSN 0730-2312. PMID 11135358.

[pmid12556451-6] Turner, Jeremy; Nicholas Hannah, Bishop David, Matthews Jacqueline M, Crossley Merlin (Apr. de 2003). «The LIM protein FHL3 binds basic Krüppel-like factor/Krüppel-like factor 3 and its co-repressor C-terminal-binding protein 2». J. Biol. Chem. (United States) 278 (15): 12786-95. ISSN 0021-9258. PMID 12556451. doi:10.1074/jbc.M300587200.

[pmid15117962-7] Samson, Thomas; Smyth Neil, Janetzky Stefanie, Wendler Olaf, Müller Judith M, Schüle Roland, von der Mark Helga, von der Mark Klaus, Wixler Viktor (Jul. de 2004). «The LIM-only proteins FHL2 and FHL3 interact with alpha- and beta-subunits of the muscle alpha7beta1 integrin receptor». J. Biol. Chem. (United States) 279 (27): 28641-52. ISSN 0021-9258. PMID 15117962. doi:10.1074/jbc.M312894200.

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Summary

Interacciones

Referencias

Enlaces externos