Cdk7 Knowpia

Quinasa dependiente de ciclina 7
	; Imagen del PDB basada en 1ua2.
Estructuras disponibles
PDB	Buscar ortólogos: PDBe, RCSB Lista de códigos PDB 1LG3 , 1PA8 , 1UA2 , 2HIC Estructuras enzimáticas RCSB PDB, PDBe, PDBsum
Identificadores
Símbolos	Cdk7 (HGNC: 1778) ; CAK1; CDKN7; HCAK; MO15; STK1; p39MO15
Identificadores; externos	OMIM: 601955 ; MGI: 102956 ; HomoloGene: 1363 ; ChEMBL: 3055; EBI: Cdk7; GeneCards: Gen Cdk7; UniProt: Cdk7; Bases de datos de enzimas IntEnz: entrada en IntEnz; BRENDA: entrada en BRENDA; ExPASy: NiceZime view; KEGG: entrada en KEEG; PRIAM: perfil PRIAM; ExplorEnz: entrada en ExplorEnz; MetaCyc: vía metabólica
Número EC	2.7.11
Locus	Cr. 5 q12.1
Función molecular	• transcription coactivator activity; • protein kinase activity; • cyclin-dependent protein serine/threonine kinase activity; • protein binding; • ATP binding; • protein C-terminus binding; • DNA-dependent ATPase activity; • RNA polymerase II carboxy-terminal domain kinase activity; • androgen receptor binding;
Componente celular	• nucleus; • nucleoplasm; • holo TFIIH complex; • cytoplasm; • mitochondrion; • perinuclear region of cytoplasm;
Proceso biológico	• regulation of cyclin-dependent protein serine/threonine kinase activity; • G1/S transition of mitotic cell cycle; • G2/M transition of mitotic cell cycle; • mitotic cell cycle; • nucleotide-excision repair, DNA damage removal; • DNA repair; • transcription-coupled nucleotide-excision repair; • nucleotide-excision repair; • transcription from RNA polymerase I promoter; • transcription initiation from RNA polymerase I promoter; • transcription elongation from RNA polymerase I promoter; • termination of RNA polymerase I transcription; • transcription from RNA polymerase II promoter; • transcription initiation from RNA polymerase II promoter; • transcription elongation from RNA polymerase II promoter; • 7-methylguanosine mRNA capping; • protein phosphorylation; • cell cycle arrest; • cell proliferation; • gene expression; • viral process; • androgen receptor signaling pathway; • regulation of gene expression, epigenetic; • negative regulation of gene expression, epigenetic; • positive regulation of transcription, DNA-templated; • positive regulation of transcription from RNA polymerase II promoter; • positive regulation of viral transcription; • cell division;
	Referencias: AmiGO / QuickGO
Patrón de expresión de ARNm
	Más información
Ortólogos
Humano	Ratón
1022	12572
Véase HS	Véase MM
P50613	Q03147
NM_001799	NM_009874
NP_001790	NP_034004
Cr. 5:; 69.23 – 69.28 Mb	Cr. 13:; 100.7 – 100.73 Mb
[1] ;	[2]
	v; t; e;
	[editar datos en Wikidata]

Proteína de división de la célula kinase 7 es una enzima que en los humanos es codificada por el gen CDK7.^[1]

La proteína codificada por este gen es un miembro del cyclin-proteína dependiente kinase (CDK) familia. CDK Los miembros familiares son altamente similares a los productos de gen de Saccharomyces cerevisiae cdc28, y Schizosaccharomyces pombe cdc2, y es sabido de ser reguladores importantes de progresión de ciclo de la célula. Esta proteína forma un complejo trimerico con la cyclin H y MAT1, el cual funciona como Cdk-activando kinase (CAK). Es un componente esencial del factor de transcripción TFIIH, implicado en la iniciación de la transcripción y reparación del ADN. Se piensa que esta quinasa sirve como enlace directo entre el control de transcripción y el ciclo celular.^[2]

Interacciones

La Cdk 7 ha demostrado ser capaz de interaccionar con:

Receptor androgénico,^[3]
Ciclina H,^[4]^[5]^[6]
GTF2H1,^[7]^[4]^[8]
MNAT1,^[4]^[9]
P53,^[10]^[11]
SUPT5H,^[6] and
XPB.^[12]^[7]^[4]

Referencias

↑ Fisher RP, Morgan DO (Aug 1994). «A novel cyclin associates with MO15/CDK7 to form the CDK-activating kinase». Cell 78 (4): 713-24. PMID 8069918. doi:10.1016/0092-8674(94)90535-5.
↑ «Entrez Gene: CDK7 cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase)».
↑ Lee DK, Duan HO, Chang C (Mar 2000). «From androgen receptor to the general transcription factor TFIIH. Identification of cdk activating kinase (CAK) as an androgen receptor NH(2)-terminal associated coactivator». The Journal of Biological Chemistry 275 (13): 9308-13. PMID 10734072. doi:10.1074/jbc.275.13.9308.
↑ ^a ^b ^c ^d Yee A, Nichols MA, Wu L, Hall FL, Kobayashi R, Xiong Y (Dec 1995). «Molecular cloning of CDK7-associated human MAT1, a cyclin-dependent kinase-activating kinase (CAK) assembly factor». Cancer Research 55 (24): 6058-62. PMID 8521393.
↑ Mäkelä TP, Tassan JP, Nigg EA, Frutiger S, Hughes GJ, Weinberg RA (Sep 1994). «A cyclin associated with the CDK-activating kinase MO15». Nature 371 (6494): 254-7. PMID 8078587. doi:10.1038/371254a0.
↑ ^a ^b Garber ME, Mayall TP, Suess EM, Meisenhelder J, Thompson NE, Jones KA (Sep 2000). «CDK9 autophosphorylation regulates high-affinity binding of the human immunodeficiency virus type 1 tat-P-TEFb complex to TAR RNA». Molecular and Cellular Biology 20 (18): 6958-69. PMC 88771. PMID 10958691. doi:10.1128/mcb.20.18.6958-6969.2000.
↑ ^a ^b Rossignol M, Kolb-Cheynel I, Egly JM (Apr 1997). «Substrate specificity of the cdk-activating kinase (CAK) is altered upon association with TFIIH». The EMBO Journal 16 (7): 1628-37. PMC 1169767. PMID 9130708. doi:10.1093/emboj/16.7.1628.
↑ Shiekhattar R, Mermelstein F, Fisher RP, Drapkin R, Dynlacht B, Wessling HC, Morgan DO, Reinberg D (Mar 1995). «Cdk-activating kinase complex is a component of human transcription factor TFIIH». Nature 374 (6519): 283-7. PMID 7533895. doi:10.1038/374283a0.
↑ Talukder AH, Mishra SK, Mandal M, Balasenthil S, Mehta S, Sahin AA, Barnes CJ, Kumar R (Mar 2003). «MTA1 interacts with MAT1, a cyclin-dependent kinase-activating kinase complex ring finger factor, and regulates estrogen receptor transactivation functions». The Journal of Biological Chemistry 278 (13): 11676-85. PMID 12527756. doi:10.1074/jbc.M209570200.
↑ Ko LJ, Shieh SY, Chen X, Jayaraman L, Tamai K, Taya Y, Prives C, Pan ZQ (Dec 1997). «p53 is phosphorylated by CDK7-cyclin H in a p36MAT1-dependent manner». Molecular and Cellular Biology 17 (12): 7220-9. PMC 232579. PMID 9372954.
↑ Schneider E, Montenarh M, Wagner P (Nov 1998). «Regulation of CAK kinase activity by p53». Oncogene 17 (21): 2733-41. PMID 9840937. doi:10.1038/sj.onc.1202504.
↑ Giglia-Mari G, Coin F, Ranish JA, Hoogstraten D, Theil A, Wijgers N, Jaspers NG, Raams A, Argentini M, van der Spek PJ, Botta E, Stefanini M, Egly JM, Aebersold R, Hoeijmakers JH, Vermeulen W (Jul 2004). «A new, tenth subunit of TFIIH is responsible for the DNA repair syndrome trichothiodystrophy group A». Nature Genetics 36 (7): 714-9. PMID 15220921. doi:10.1038/ng1387.

Datos: Q18021240

[pmid8069918-1] Fisher RP, Morgan DO (Aug 1994). «A novel cyclin associates with MO15/CDK7 to form the CDK-activating kinase». Cell 78 (4): 713-24. PMID 8069918. doi:10.1016/0092-8674(94)90535-5.

[entrez-2] «Entrez Gene: CDK7 cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase)».

[pmid10734072-3] Lee DK, Duan HO, Chang C (Mar 2000). «From androgen receptor to the general transcription factor TFIIH. Identification of cdk activating kinase (CAK) as an androgen receptor NH(2)-terminal associated coactivator». The Journal of Biological Chemistry 275 (13): 9308-13. PMID 10734072. doi:10.1074/jbc.275.13.9308.

[pmid8521393-4] Yee A, Nichols MA, Wu L, Hall FL, Kobayashi R, Xiong Y (Dec 1995). «Molecular cloning of CDK7-associated human MAT1, a cyclin-dependent kinase-activating kinase (CAK) assembly factor». Cancer Research 55 (24): 6058-62. PMID 8521393.

[pmid8078587-5] Mäkelä TP, Tassan JP, Nigg EA, Frutiger S, Hughes GJ, Weinberg RA (Sep 1994). «A cyclin associated with the CDK-activating kinase MO15». Nature 371 (6494): 254-7. PMID 8078587. doi:10.1038/371254a0.

[pmid10958691-6] Garber ME, Mayall TP, Suess EM, Meisenhelder J, Thompson NE, Jones KA (Sep 2000). «CDK9 autophosphorylation regulates high-affinity binding of the human immunodeficiency virus type 1 tat-P-TEFb complex to TAR RNA». Molecular and Cellular Biology 20 (18): 6958-69. PMC 88771. PMID 10958691. doi:10.1128/mcb.20.18.6958-6969.2000.

[pmid9130708-7] Rossignol M, Kolb-Cheynel I, Egly JM (Apr 1997). «Substrate specificity of the cdk-activating kinase (CAK) is altered upon association with TFIIH». The EMBO Journal 16 (7): 1628-37. PMC 1169767. PMID 9130708. doi:10.1093/emboj/16.7.1628.

[pmid7533895-8] Shiekhattar R, Mermelstein F, Fisher RP, Drapkin R, Dynlacht B, Wessling HC, Morgan DO, Reinberg D (Mar 1995). «Cdk-activating kinase complex is a component of human transcription factor TFIIH». Nature 374 (6519): 283-7. PMID 7533895. doi:10.1038/374283a0.

[pmid12527756-9] Talukder AH, Mishra SK, Mandal M, Balasenthil S, Mehta S, Sahin AA, Barnes CJ, Kumar R (Mar 2003). «MTA1 interacts with MAT1, a cyclin-dependent kinase-activating kinase complex ring finger factor, and regulates estrogen receptor transactivation functions». The Journal of Biological Chemistry 278 (13): 11676-85. PMID 12527756. doi:10.1074/jbc.M209570200.

[pmid9372954-10] Ko LJ, Shieh SY, Chen X, Jayaraman L, Tamai K, Taya Y, Prives C, Pan ZQ (Dec 1997). «p53 is phosphorylated by CDK7-cyclin H in a p36MAT1-dependent manner». Molecular and Cellular Biology 17 (12): 7220-9. PMC 232579. PMID 9372954.

[pmid9840937-11] Schneider E, Montenarh M, Wagner P (Nov 1998). «Regulation of CAK kinase activity by p53». Oncogene 17 (21): 2733-41. PMID 9840937. doi:10.1038/sj.onc.1202504.

[pmid15220921-12] Giglia-Mari G, Coin F, Ranish JA, Hoogstraten D, Theil A, Wijgers N, Jaspers NG, Raams A, Argentini M, van der Spek PJ, Botta E, Stefanini M, Egly JM, Aebersold R, Hoeijmakers JH, Vermeulen W (Jul 2004). «A new, tenth subunit of TFIIH is responsible for the DNA repair syndrome trichothiodystrophy group A». Nature Genetics 36 (7): 714-9. PMID 15220921. doi:10.1038/ng1387.

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Summary

Interacciones

Referencias