CUL3 Knowpia

Culina 3
	; Estructura tridimensional de la proteína CUL3.
Estructuras disponibles
PDB	Buscar ortólogos: PDBe, RCSB Lista de códigos PDB 1iuy
Identificadores
Símbolo	CUL3 (HGNC: 2553)
Identificadores; externos	OMIM: 603136 ; EBI: CUL3; GeneCards: Gen CUL3; UniProt: CUL3;
Locus	Cr. 2 q36.2
	Referencias: AmiGO / QuickGO
Ortólogos
Humano	Ratón
8452
Q13618	n/a
NP_003581	n/a
	v; t; e;
	[editar datos en Wikidata]

La culina 3, también denominada CUL3, es una proteína codificada en humanos por el gen cul3.^[1]^[2]^[3]

Interacciones

La proteína CUL3 ha demostrado ser capaz de interaccionar con:

KLHL12^[4]
CAND1^[5]
KEAP1^[6]^[7]
DCUN1D1^[8]
Ciclina E1^[9]

Referencias

↑ Kipreos ET, Lander LE, Wing JP, He WW, Hedgecock EM (Aug de 1996). «cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family». Cell 85 (6): 829-39. PMID 8681378.
↑ Wimuttisuk W, Singer JD (Feb de 2007). «The Cullin3 ubiquitin ligase functions as a Nedd8-bound heterodimer». Mol Biol Cell 18 (3): 899-909. PMC 1805106. PMID 17192413. doi:10.1091/mbc.E06-06-0542.
↑ «Entrez Gene: CUL3 cullin 3».
↑ Rondou, Pieter; Haegeman Guy, Vanhoenacker Peter, Van Craenenbroeck Kathleen (Apr. de 2008). «BTB Protein KLHL12 targets the dopamine D4 receptor for ubiquitination by a Cul3-based E3 ligase». J. Biol. Chem. (United States) 283 (17): 11083-96. ISSN 0021-9258. PMID 18303015. doi:10.1074/jbc.M708473200.
↑ Min, Kyoeng-Woo; Hwang Ji-Won, Lee Jong-Sik, Park Yoon, Tamura Taka-aki, Yoon Jong-Bok (mayo. de 2003). «TIP120A associates with cullins and modulates ubiquitin ligase activity». J. Biol. Chem. (United States) 278 (18): 15905-10. ISSN 0021-9258. PMID 12609982. doi:10.1074/jbc.M213070200.
↑ Wang, Xiao-Jun; Sun Zheng, Chen Weimin, Li Yanjie, Villeneuve Nicole F, Zhang Donna D (Aug. de 2008). «Activation of Nrf2 by arsenite and monomethylarsonous acid is independent of Keap1-C151: enhanced Keap1-Cul3 interaction». Toxicol. Appl. Pharmacol. (United States) 230 (3): 383-9. ISSN 0041-008X. PMID 18417180. doi:10.1016/j.taap.2008.03.003.
↑ Rachakonda, Girish; Xiong Ying, Sekhar Konjeti R, Stamer Sheryl L, Liebler Daniel C, Freeman Michael L (Mar. de 2008). «Covalent modification at Cys151 dissociates the electrophile sensor Keap1 from the ubiquitin ligase CUL3». Chem. Res. Toxicol. (United States) 21 (3): 705-10. ISSN 0893-228X. PMID 18251510. doi:10.1021/tx700302s.
↑ Kim, Alexander Y; Bommeljé Claire C, Lee Benjamin E, Yonekawa Yoshihiro, Choi Lydia, Morris Luc G, Huang Guochang, Kaufman Andrew, Ryan Russel J H, Hao Bing, Ramanathan Y, Singh Bhuvanesh (Nov. de 2008). «SCCRO (DCUN1D1) is an essential component of the E3 complex for neddylation». J. Biol. Chem. (United States) 283 (48): 33211-20. ISSN 0021-9258. PMID 18826954. doi:10.1074/jbc.M804440200.
↑ Singer, J D; Gurian-West M, Clurman B, Roberts J M (Sep. de 1999). «Cullin-3 targets cyclin E for ubiquitination and controls S phase in mammalian cells». Genes Dev. (UNITED STATES) 13 (18): 2375-87. ISSN 0890-9369. PMID 10500095.

Datos: Q18032944

[pmid8681378-1] Kipreos ET, Lander LE, Wing JP, He WW, Hedgecock EM (Aug de 1996). «cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family». Cell 85 (6): 829-39. PMID 8681378.

[pmid17192413-2] Wimuttisuk W, Singer JD (Feb de 2007). «The Cullin3 ubiquitin ligase functions as a Nedd8-bound heterodimer». Mol Biol Cell 18 (3): 899-909. PMC 1805106. PMID 17192413. doi:10.1091/mbc.E06-06-0542.

[entrez-3] «Entrez Gene: CUL3 cullin 3».

[pmid18303015-4] Rondou, Pieter; Haegeman Guy, Vanhoenacker Peter, Van Craenenbroeck Kathleen (Apr. de 2008). «BTB Protein KLHL12 targets the dopamine D4 receptor for ubiquitination by a Cul3-based E3 ligase». J. Biol. Chem. (United States) 283 (17): 11083-96. ISSN 0021-9258. PMID 18303015. doi:10.1074/jbc.M708473200.

[pmid12609982-5] Min, Kyoeng-Woo; Hwang Ji-Won, Lee Jong-Sik, Park Yoon, Tamura Taka-aki, Yoon Jong-Bok (mayo. de 2003). «TIP120A associates with cullins and modulates ubiquitin ligase activity». J. Biol. Chem. (United States) 278 (18): 15905-10. ISSN 0021-9258. PMID 12609982. doi:10.1074/jbc.M213070200.

[pmid18417180-6] Wang, Xiao-Jun; Sun Zheng, Chen Weimin, Li Yanjie, Villeneuve Nicole F, Zhang Donna D (Aug. de 2008). «Activation of Nrf2 by arsenite and monomethylarsonous acid is independent of Keap1-C151: enhanced Keap1-Cul3 interaction». Toxicol. Appl. Pharmacol. (United States) 230 (3): 383-9. ISSN 0041-008X. PMID 18417180. doi:10.1016/j.taap.2008.03.003.

[pmid18251510-7] Rachakonda, Girish; Xiong Ying, Sekhar Konjeti R, Stamer Sheryl L, Liebler Daniel C, Freeman Michael L (Mar. de 2008). «Covalent modification at Cys151 dissociates the electrophile sensor Keap1 from the ubiquitin ligase CUL3». Chem. Res. Toxicol. (United States) 21 (3): 705-10. ISSN 0893-228X. PMID 18251510. doi:10.1021/tx700302s.

[pmid18826954-8] Kim, Alexander Y; Bommeljé Claire C, Lee Benjamin E, Yonekawa Yoshihiro, Choi Lydia, Morris Luc G, Huang Guochang, Kaufman Andrew, Ryan Russel J H, Hao Bing, Ramanathan Y, Singh Bhuvanesh (Nov. de 2008). «SCCRO (DCUN1D1) is an essential component of the E3 complex for neddylation». J. Biol. Chem. (United States) 283 (48): 33211-20. ISSN 0021-9258. PMID 18826954. doi:10.1074/jbc.M804440200.

[pmid10500095-9] Singer, J D; Gurian-West M, Clurman B, Roberts J M (Sep. de 1999). «Cullin-3 targets cyclin E for ubiquitination and controls S phase in mammalian cells». Genes Dev. (UNITED STATES) 13 (18): 2375-87. ISSN 0890-9369. PMID 10500095.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

Summary

Interacciones

Referencias