CDKN3 Knowpia

Inhibidor 3 de quinasa dependiente de ciclina
	; Estructura tridimensional de la proteína CDKN3.
Estructuras disponibles
PDB	Buscar ortólogos: PDBe, RCSB Lista de códigos PDB 1fpz
Identificadores
Símbolos	CDKN3 (HGNC: 1791) CDI1, CIP2, FLJ25787, KAP; KAP1, MGC70625
Identificadores; externos	OMIM: 123832 ; EBI: CDKN3; GeneCards: Gen CDKN3; UniProt: CDKN3;
Locus	Cr. 14 q22.2
	Referencias: AmiGO / QuickGO
Ortólogos
Humano	Ratón
1033
Q16667	n/a
NP_005183	n/a
	v; t; e;
	[editar datos en Wikidata]

El inhibidor 3 de quinasa dependiente de ciclina (CDKN3) es una enzima codificada en humanos por el gen cdkn3.^[1]^[2]^[3]

La proteína CDKN3 pertenece a la familia de proteínas fosfatasas duales específicas. Fue identificado inicialmente como un inhibidor de quinasa dependiente de ciclina y ha demostrado interaccionar y defosforilar a Cdk2, por lo que impide la activación de esta quinasa. Este gen se ha encontrado delecionado, mutado o hiper-expresado en diversos tipos de cáncer.^[3]

Interacciones

La proteína Cdk2 ha demostrado ser capaz de interaccionar con:

Cdk2^[4]^[5]^[6]
Cdk1^[5]^[1]
MS4A3^[7]

Referencias

↑ ^a ^b Gyuris J, Golemis E, Chertkov H, Brent R (Dec de 1993). «Cdi1, a human G1 and S phase protein phosphatase that associates with Cdk2». Cell (EE. UU.) 75 (4): 791-803. ISSN 0092-8674. PMID 8242750.
↑ Demetrick DJ, Matsumoto S, Hannon GJ, Okamoto K, Xiong Y, Zhang H, Beach DH (mayo de 1995). «Chromosomal mapping of the genes for the human cell cycle proteins cyclin C (CCNC), cyclin E (CCNE), p21 (CDKN1) and KAP (CDKN3)». Cytogenet Cell Genet 69 (3-4): 190-2. PMID 7698009.
↑ ^a ^b «Entrez Gene: CDKN3 cyclin-dependent kinase inhibitor 3 (CDK2-associated dual specificity phosphatase)».
↑ Yeh, Chau-Ting; Lu Su-Chuan, Chao Chung-Hao, Chao Mei-Ling (mayo. de 2003). «Abolishment of the interaction between cyclin-dependent kinase 2 and Cdk-associated protein phosphatase by a truncated KAP mutant». Biochem. Biophys. Res. Commun. (United States) 305 (2): 311-4. ISSN 0006-291X. PMID 12745075.
↑ ^a ^b Hannon, G J; Casso D; Beach D (Mar. de 1994). «KAP: a dual specificity phosphatase that interacts with cyclin-dependent kinases». Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 91 (5): 1731-5. ISSN 0027-8424. PMID 8127873.
↑ Harper, J W; Adami G R, Wei N, Keyomarsi K, Elledge S J (Nov. de 1993). «The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases». Cell (UNITED STATES) 75 (4): 805-16. ISSN 0092-8674. PMID 8242751.
↑ Donato, José L; Ko Jon, Kutok Jeffery L, Cheng Tao, Shirakawa Taro, Mao Xiao-Quan, Beach David, Scadden David T, Sayegh Mohamed H, Adra Chaker N (Jan. de 2002). «Human HTm4 is a hematopoietic cell cycle regulator». J. Clin. Invest. (United States) 109 (1): 51-8. ISSN 0021-9738. PMID 11781350. doi:10.1172/JCI14025.

Datos: Q17860603

[pmid8242750-1] Gyuris J, Golemis E, Chertkov H, Brent R (Dec de 1993). «Cdi1, a human G1 and S phase protein phosphatase that associates with Cdk2». Cell (EE. UU.) 75 (4): 791-803. ISSN 0092-8674. PMID 8242750.

[pmid7698009-2] Demetrick DJ, Matsumoto S, Hannon GJ, Okamoto K, Xiong Y, Zhang H, Beach DH (mayo de 1995). «Chromosomal mapping of the genes for the human cell cycle proteins cyclin C (CCNC), cyclin E (CCNE), p21 (CDKN1) and KAP (CDKN3)». Cytogenet Cell Genet 69 (3-4): 190-2. PMID 7698009.

[entrez-3] «Entrez Gene: CDKN3 cyclin-dependent kinase inhibitor 3 (CDK2-associated dual specificity phosphatase)».

[pmid12745075-4] Yeh, Chau-Ting; Lu Su-Chuan, Chao Chung-Hao, Chao Mei-Ling (mayo. de 2003). «Abolishment of the interaction between cyclin-dependent kinase 2 and Cdk-associated protein phosphatase by a truncated KAP mutant». Biochem. Biophys. Res. Commun. (United States) 305 (2): 311-4. ISSN 0006-291X. PMID 12745075.

[pmid8127873-5] Hannon, G J; Casso D; Beach D (Mar. de 1994). «KAP: a dual specificity phosphatase that interacts with cyclin-dependent kinases». Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 91 (5): 1731-5. ISSN 0027-8424. PMID 8127873.

[pmid8242751-6] Harper, J W; Adami G R, Wei N, Keyomarsi K, Elledge S J (Nov. de 1993). «The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases». Cell (UNITED STATES) 75 (4): 805-16. ISSN 0092-8674. PMID 8242751.

[pmid11781350-7] Donato, José L; Ko Jon, Kutok Jeffery L, Cheng Tao, Shirakawa Taro, Mao Xiao-Quan, Beach David, Scadden David T, Sayegh Mohamed H, Adra Chaker N (Jan. de 2002). «Human HTm4 is a hematopoietic cell cycle regulator». J. Clin. Invest. (United States) 109 (1): 51-8. ISSN 0021-9738. PMID 11781350. doi:10.1172/JCI14025.

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Summary

Interacciones

Referencias