A continuación se listan los embajadores de los Estados Unidos en el Uruguay.

• Alexander Asboth 1867 - 1868
• H. G. Worthington 1868 - 1869
• Robert C. Kirk 1869 - 1870
• John L. Stevens 1870 - 1873
• John C. Caldwell 1874 - 1882
• William Williams 1882 - 1885
• John E. Bacon 1885 - 1888
• George Maney 1889 - 1894
• Granville Stuart 1894 - 1898
• William R. Finch 1898 - 1905
• Edward C. O'Brien 1905 - 1909
• Edwin V. Morgan 1910 - 1911
• Nicolai A. Grevstad 1911 - 1914
• Robert Emmett Jeffery 1915 - 1921
• Hoffman Philip 1922 - 1925
• Ulysses Grant-Smith 1925 - 1929
• Leland Harrison 1930 - 1930
• J. Butler Wright 1931 - 1934
• Julius G. Lay 1935 - 1937
• William Dawson 1938 - 1939
• Edwin C. Wilson 1939 - 1941
• William Dawson 1941 - 1946
• Joseph F. McGurk 1946 - 1947
• Ellis O. Briggs 1947 - 1949
• Christian M. Ravndal 1949 - 1951
• Edward L. Rodden 1951 - 1953
• Dempster McIntosh 1953 - 1956
• Jefferson Patterson 1956 - 1958
• Robert F. Woodward 1958 - 1961
• Edward J. Sparks 1961 - 1962
• Wymberley DeRenne Coerr 1962 - 1965
• Henry A. Hoyt 1965 - 1967
• Robert M. Sayre 1968 - 1969
• Charles W. Adair, Jr. 1969 - 1972
• Ernest V. Siracusa 1973 - 1977
• Lawrence Pezzulo 1977 - 1979
• Lyle Franklin Lane 1979 - 1980
• N. Shaw Smith 1980 - 1981
• Thomas Aranda, Jr. 1981 - 1985
• Malcolm Richard Wilkey 1985 - 1990
• Richard C. Brown 1990 - 1993
• Thomas J. Dodd, Jr. 1993 - 1997
• Christopher C. Ashby 1997 - 2001
• Martin J. Silverstein 2001 - 2005
• Frank E. Baxter 2006 - 2009
• David Daniel Nelson 2009 - 2011
• Thomas H. Lloyd 2011 - 2012
• Julissa Reynoso 2012 - 2015
• Kelly Keiderling 2016 - 2019
• Kenn George 2019 - 2022
• Heide B. Fulton 2023 - 2025